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IL6 — PGF

Text-mined interactions from Literome

Tokuda et al., Cell Signal 1999 : PD98059, a selective inhibitor of MAP kinase kinase, inhibited PGF2alpha induced interleukin-6 (IL-6) synthesis as well as PGF2alpha induced p42/p44 MAP kinase activation ... These results strongly suggest that PKC dependent p42/p44 MAP kinase activatioin is involved in PGF2alpha induced IL-6 synthesis in osteoblasts
Shinoda et al., Cell Signal 1999 : We previously showed that prostaglandin ( PG ) E1 stimulates the synthesis of interleukin-6 (IL-6) through activation of protein kinase (PK) A in osteoblast-like MC3T3-E1 cells and that PGF2alpha induces IL-6 synthesis through PKC activation ... C2-ceramide inhibited the IL-6 synthesis induced by PGF2alpha or 12-O-tetradecanoylphorbol-13-acetate, an activator of PKC
Ma et al., Arzneimittelforschung 2000 : Furthermore, intraperitoneal injection with indometacin ( CAS 53-86-1 ) 10 mg/kg daily for 5 days reduced the IL-6 induced increase in 6-keto-PGF1 alpha levels
Noguchi et al., J Periodontal Res 2001 (Periodontal Diseases) : In the present study, we investigated the effect of PGF2alpha on interleukin (IL)-6 production in human gingival fibroblasts (HGF) ... PGF2alpha stimulated IL-6 production in a time- and concentration dependent fashion ... IL-6 mRNA was expressed in PGF2alpha stimulated HGF, and PGF2alpha increased IL-6 mRNA levels induced by IL-1beta and TNFalpha ... Fluprostenol, a selective FP receptor agonist, could mimic PGF2alpha induced IL-6 production ... TMB-8 significantly suppressed PGF2alpha induced IL-6 production, whereas calphostin C showed a stimulatory effect on PGF2alpha induced IL-6 production ... From these data, we suggest that PGF2alpha upregulates IL-6 production through FP receptors in HGF, that PGF2alpha synergistically enhances IL-6 production in IL-1beta- and TNFalpha stimulated HGF, and that PGF2alpha induced IL-6 production may be dependent on intracellular Ca2+ mobilization and be downregulated by PKC activation ... PGF2alpha may be involved in the pathogenesis of periodontal disease by enhancing IL-6 levels in periodontal lesions
Hatakeyama et al., J Cell Biochem 2002 : In the present study, we investigated whether zinc affects the PGF2alpha induced IL-6 synthesis in these cells ... Zinc complex of l-carnosine ( l-CAZ ) dose-dependently suppressed the PGF2alpha stimulated IL-6 synthesis ... These results strongly suggest that zinc reduces PGF2alpha induced IL-6 synthesis via suppression of phosphoinositide hydrolyzing phospholipase C and phosphatidylcholine hydrolyzing phospholipase D in osteoblasts
Peng et al., Zhonghua Fu Chan Ke Za Zhi 2003 : [ Study on regulatory effects of interleukin-6 on placental growth factor expression in trophoblast cells ] ... To investigate the expression pattern of Placental growth factor (PlGF) and regulatory effects of interleukin-6 (IL-6) on PlGF expression in the primary cultured trophoblast cells ... The effects of IL-6 with different concentration ( 100, 10, 1 and 0.1 microg/L ) and duration ( 6, 12, 24 and 48 h ) on PlGF expression were observed
Sakumoto et al., Domest Anim Endocrinol 2006 : Neither IL-4 nor IL-6 had any effect on PGF2alpha secretion by the cells
Minamitani et al., Mol Cell Endocrinol 2008 : SB203580 and BIRB0796, potent inhibitors of p38 MAP kinase, suppressed the IL-6 synthesis induced by PGF ( 2alpha )
Yoo et al., Arthritis Rheum 2009 (Arthritis, Experimental...) : Exogenous PlGF specifically increased the production of TNFalpha and IL-6 in mononuclear cells from RA patients ( but not those from healthy controls ) via a calcineurin dependent pathway ... A novel anti-flt-1 hexapeptide, GNQWFI, abrogated the PlGF induced increase in TNFalpha and IL-6 production, and also suppressed CII induced arthritis and serum IL-6 concentrations in mice
Franczak et al., Theriogenology 2012 : We studied the effect of tumor necrosis factor a (TNFa), interleukin 1ß (IL1ß) and interleukin 6 (IL6) on : 1 ) endometrial release of prostaglandin F2a (PGF2a) , 2 ) expression of the terminal enzyme of PGF2a synthesis -- PGF synthase mRNA (PGFS mRNA), 3 ) secretion of PGF ( 2 ) a metabolite -- 13,14-dihydro-15-keto PGF2a ( PGFM ) by the endometrium and 4 ) presence and activity of endometrial NAD dependent 15-hydroxyprostaglandin dehydrogenase ( 15-PGDH ) ... IL6 increased PGF2a release mainly on days 15-16 of pregnancy ... These data provide new evidence that TNFa, IL1ß, IL6 are involved in the regulation of endometrial synthesis, release and metabolism of PGF2a to protect CL during early pregnancy or to facilitate its regression in cyclic females
Lappas et al., Mol Hum Reprod 2012 : PLGF significantly increased interleukin (IL)-6 and IL-8 gene expression and secretion, cyclooxygenase-2 expression and resultant prostaglandin ( PG ) E ( 2 ) and PGF ( 2a ) release, and MMP-9 gene expression and enzyme production
Kent et al., Prostaglandins 1993 : IL-6 had no effect on decidual PGF2 alpha production
Kozawa et al., Am J Physiol 1997 : In the present study, we examined the effect of PGF2alpha on synthesis of interleukin-6 (IL-6) and the involvement of protein kinase C ( PKC ) activation in the IL-6 synthesis in these cells ... PGF2alpha significantly stimulated IL-6 synthesis in a dose dependent manner in the range between 10 nM and 10 microM ... Staurosporine, an inhibitor for protein kinases that suppressed the TPA induced IL-6 synthesis, significantly inhibited the PGF2alpha induced IL-6 synthesis ... Calphostin C, a highly specific PKC inhibitor, also suppressed the PGF2alpha stimulated synthesis of IL-6 ... The effect of PGF2alpha on IL-6 synthesis in PKC downregulated cells was much weaker than that in intact cells ... These results strongly suggest that PGF2alpha induces IL-6 synthesis via PKC activation in osteoblast-like cells
Tokuda et al., Endocrinology 1998 : In osteoblast-like MC3T3-E1 cells, we recently reported that PGE1 and PGF2alpha induce interleukin (IL)-6 synthesis via activation of protein kinase A and protein kinase C, respectively ... In addition, T3 reduced PGF2alpha induced IL-6 synthesis dose dependently in the range between 10 pM and 10 nM
Kozawa et al., Prostaglandins Leukot Essent Fatty Acids 1998 : 1,25-Dihydroxyvitamin D3 ( 1,25- ( OH ) 2D3 ), an active form of vitamin D3, inhibited the IL-6 synthesis induced by PGF2alpha or PGE1
Tokuda et al., J Cell Biochem 1998 : In previous studies, we have reported that PGF2alpha stimulates phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D through heterotrimeric GTP binding protein in osteoblast-like MC3T3-E1 cells, and that PGF2alpha and PGE1 induce interleukin-6 (IL-6) synthesis via activation of protein kinase C and protein kinase A, respectively ... Tiludronate significantly suppressed the PGF2alpha induced IL-6 secretion in a dose dependent manner in the range between 0.1 and 30 microM ... These results strongly suggest that tiludronate inhibits PGF2alpha induced IL-6 synthesis via suppression of phosphatidylcholine hydrolyzing phospholipase D activation in osteoblasts, and that the inhibitory effect is exerted at the point between heterotrimeric GTP binding protein and phospholipase D
Kozawa et al., Prostaglandins Leukot Essent Fatty Acids 1998 : Retinoic acid inhibited the IL-6 synthesis induced by PGF2alpha or PGE1 in a dose dependent manner in the range between 0.1 and 10 nM ... These results indicate that retinoic acid inhibits IL-6 synthesis induced by prostaglandins in osteoblasts as follows : the inhibitory effect on the PGE1 induced IL-6 synthesis is exerted at a point downstream from cAMP, and the inhibitory effect on the PGF2alpha induced IL-6 synthesis is exerted at a point downstream from protein kinase C