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BCR — ZAP70

Text-mined interactions from Literome

Chen et al., Blood 2002 (Diseases in Twins...) : Following BCR ligation, ZAP-70 underwent tyrosine phosphorylation and became associated with surface immunoglobulin and CD79b, arguing for the involvement of ZAP-70 in BCR signaling
Gobessi et al., Blood 2007 (Leukemia, B-Cell...) : We show that BCR mediated activation of ZAP-70 is very inefficient in CLL and lymphoma B cells and is negligible when compared to activation of Syk ... We conclude that the role of ZAP-70 in BCR signaling is quite distinct from its role in TCR signaling and is likely mediated by inhibition of events that terminate the signaling response