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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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EPHB2 — GDF15

Text-mined interactions from Literome

Gerecke et al., Mol Cell Neurosci 2004 : NRG-1beta effects on neurite extension and arborization are similar to, but not additive with, those of brain derived neurotrophic factor and reflect direct NRG-1 action on hippocampal neurons as these cells express the NRG-1 receptors erbB2 and erbB4, the erbB-specific inhibitor PD158780 decreases NRG-1beta induced neurite outgrowth, and NRG-1beta stimulation induces p42/44 ERK phosphorylation
Wollmann et al., Carcinogenesis 2005 (Breast Neoplasms) : MIC-1 increased the basal ERK1 phosphorylation and prolonged the estrogen stimulated ERK1 phosphorylation in MCF-7 breast cancer cells without altering the phosphorylation status of AKT/PKB
Nakaoka et al., J Clin Invest 2007 (Cardiovascular Abnormalities...) : NRG-1beta induced activation of both ERK and AKT in the hearts of control mice but not in those of DKO mice
Kim et al., Cancer Lett 2008 (Breast Neoplasms...) : Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 MAPK, but not by the activation of JNK, ERK , and NF-kappaB pathway
Park et al., BMB Rep 2010 (Breast Neoplasms) : MIC-1 induced significant phosphorylation of EGFR at Tyr845, ErbB2 at Tyr877, and ErbB3 at Tyr1289 as well as Akt and p38, Erk1/2 , and JNK mitogen activated protein kinases ( MAPKs )
Yu et al., J Cell Physiol 2012 (Adenocarcinoma...) : Furthermore, the activity of ERK1/2 was enhanced by the combination of K8 and paclitaxel, and an ERK1/2 inhibitor dramatically inhibited NAG-1 expression in human lung cancer cells
Choi et al., Protein & cell 2012 (MAP Kinase Signaling System) : While over expression of the intact human HER3 transformed CHO cells with oncogenic properties such as AKT/ERK activation and increased proliferation and migration, CHO cells expressing the HER3-2-3 chimeric receptor showed significantly reduced HER3/HER2 dimerization and decreased phosphorylation of both AKT and ERK1/2 in the presence of neuregulin-1 (NRG-1)