Gene interactions and pathways from curated databases and text-mining

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HMGB1 — IRAK2

Pathways - manually collected, often from reviews:

  • NCI Pathway Database Endogenous TLR signaling: IRAK2 (IRAK2) → HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP) (modification, collaborate)
    Park et al., J Biol Chem 2004
    Evidence: mutant phenotype, other species
  • NCI Pathway Database Endogenous TLR signaling: IRAK2 (IRAK2) → HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
    Park et al., J Biol Chem 2004
    Evidence: mutant phenotype, other species
  • NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP) → HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
    Park et al., J Biol Chem 2004
    Evidence: mutant phenotype, other species
  • NCI Pathway Database Endogenous TLR signaling: IRAK4 (IRAK4) → HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
    Park et al., J Biol Chem 2004
    Evidence: mutant phenotype, other species
  • NCI Pathway Database Endogenous TLR signaling: IRAK (IRAK1) → HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
    Park et al., J Biol Chem 2004
    Evidence: mutant phenotype, other species
  • NCI Pathway Database Endogenous TLR signaling: IRAK2 (IRAK2) → HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP) (modification, collaborate)
    Park et al., J Biol Chem 2004
    Evidence: mutant phenotype, other species
  • NCI Pathway Database Endogenous TLR signaling: IRAK2 (IRAK2) → HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
    Park et al., J Biol Chem 2004
    Evidence: mutant phenotype, other species
  • NCI Pathway Database Endogenous TLR signaling: IRAK4 (IRAK4) → HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
    Park et al., J Biol Chem 2004
    Evidence: mutant phenotype, other species
  • NCI Pathway Database Endogenous TLR signaling: IRAK (IRAK1) → HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
    Park et al., J Biol Chem 2004
    Evidence: mutant phenotype, other species
  • NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP) → HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
    Park et al., J Biol Chem 2004
    Evidence: mutant phenotype, other species