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NOTCH4 — SHH
Text-mined interactions from Literome
Androutsellis-Theotokis et al., Nature 2006
(Second Messenger Systems) :
Here we show that
Notch receptor activation
induces the expression of the specific target genes hairy and enhancer of split 3 (Hes3) and
Sonic hedgehog (Shh) through rapid activation of cytoplasmic signals, including the serine/threonine kinase Akt, the transcription factor STAT3 and mammalian target of rapamycin, and thereby promotes the survival of neural stem cells
Crawford et al., Dev Dyn 2007
:
During development of the neural tube, inhibition of the
Notch response as well as the
activation of the
Sonic Hedgehog (Shh) response results in the formation of neuronal cell types