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SHH — TCF20
Text-mined interactions from Literome
Chen et al., Development 2004
(Polydactyly) :
Shh regulates digit formation largely by preventing cleavage of the Gli3
transcription factor to a repressor form that shuts off expression of Shh target genes
Colvin Wanshura et al., Cancer Res 2011
(Cell Transformation, Neoplastic...) :
We report that the
transcription factor and oncogene Snail1 ( Sna1 ) is directly
induced by
Shh pathway activity in GCPs, murine medulloblastomas, and human medulloblastoma cells
Harris et al., Oncogene 2012
(Breast Neoplasms...) :
In these cells,
SHH caused activation of the Hh
transcription factor , GLI1, leading to upregulated expression of the potent pro-angiogenic secreted molecule, CYR61 ( cysteine-rich angiogenic inducer 61 )
Tanabe et al., Cell 1998
:
Our results suggest that the
Shh mediated induction of a single
transcription factor , MNR2, is sufficient to direct somatic motor neuron differentiation