Gene interactions and pathways from curated databases and text-mining

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APOB — TP53

Text-mined interactions from Literome

Napoli et al., FASEB J 2000 (Arteriosclerosis) : Mildly oxidized LDL also activated MAP and Jun kinases and increased p53 and other transcription factors ( ATF-2, ELK-1, CREB, AP-1 )
Mazière et al., Biochem Biophys Res Commun 2000 : Oxidized LDL induces an oxidative stress and activates the tumor suppressor p53 in MRC5 human fibroblasts
Heinloth et al., Atherosclerosis 2002 : Nitric oxide prevents oxidised LDL induced p53 accumulation, cytochrome c translocation, and apoptosis in macrophages via guanylate cyclase stimulation
Choi et al., J Nutr 2008 : Moreover, oxidized LDL increased luciferase activity of p53 in endothelial cells transfected with a p53 promoter construct, the increase of which was strikingly downregulated by EGCG and hesperetin