◀ Back to TP53
HRAS — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Deguin-Chambon et al., Oncogene 2000
:
We therefore suggest that, by
inducing c-Ha-Ras ,
p53 activates a positive feedback loop that counteracts the negative feedback loop mediated by Mdm2
Bulavin et al., Mol Cell Biol 2003
(MAP Kinase Signaling System) :
Inhibition of p38 mitogen activated protein kinase ( MAPK ) activation correlated with the deregulation of p53 activation, and both a p38 MAPK chemical inhibitor and the expression of a dominant negative p38alpha inhibited
p53 activation in the
presence of
H-ras in wild-type MEF
Sashida et al., Mol Cell Biol 2009
(Cell Transformation, Neoplastic) :
Even though
p53 is absent in Elf4 ( -/- ) p53 ( -/- ) mef 's, neither oncogenic
H-Ras ( V12 ) nor c-myc can
induce transformation of these cells
Zhang et al., Int J Oncol 1995
:
Without this element, wild-type
p53 represses the
H-ras promoter, as do several p53 mutants
Zoumpourlis et al., Int J Oncol 1995
:
These experimental results suggest a direct
role of
p53 in regulation of
H-ras
Sanchezprieto et al., Oncol Rep 1995
:
We show that v-myc and
v-H-ras oncogenes increase sensitivity in both cell types and that Neu and mutant
p53 also
increase sensitivity to tamoxifen, more significantly in the epithelial cells