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RREB1 — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Huang et al., Nature 2007
:
p53 is
regulated by the lysine demethylase
LSD1
Liu et al., Biochem J 2009
:
Silencing of
RREB-1 significantly
reduces p53 expression at both the mRNA and the protein levels ... Notably, disruption of
RREB-1 mediated
p53 transcription suppresses the expression of the p53 target genes ... We also show that, upon exposure to genotoxic stress,
RREB-1 controls apoptosis in a
p53 dependent manner