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HNRNPF — TGFB1
Text-mined interactions from Literome
Strobl et al., Microbes Infect 1999
:
TGF-beta1 inhibits upregulation of critical T-cell costimulatory molecules on the surface of DCs and
reduces the antigen presenting capacity of
DCs
Sato et al., J Immunol 2000
:
Stimulation of mature
DCs with
TGF-beta 1 also enhanced TNF-alpha induced down-regulation of the expressions of CCR-1, CCR-3, CCR-5, CCR-6, and CXCR-4, and chemotaxis to their respective ligands, while this stimulation suppressed TNF-alpha induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta
Luo et al., Proc Natl Acad Sci U S A 2007
(Diabetes Mellitus, Type 1) :
Here we show that beta-cell peptide pulsed
dendritic cells (DCs) from nonobese diabetic ( NOD ) mice can effectively induce CD4 ( + ) CD25 ( + ) Foxp3 ( + ) T cells from naïve islet-specific CD4 ( + ) CD25 ( - ) T cells in the
presence of
TGF-beta1
Ojima et al., Int J Oncol 2007
:
Furthermore, the transduction of the GM-CSF gene into DCs also suppressed the incidence of apoptosis of
DCs induced by
transforming growth factor-beta1 ( TGFbeta-1 )
Dumitriu et al., J Immunol 2009
(Carcinoma, Non-Small-Cell Lung...) :
Using gene expression analysis, we found that human
DCs increased the expression of
TGF-beta1 transcripts following culture with human lung carcinoma cells ( LCCs )
Kushwah et al., J Immunol 2009
:
Additionally, apoptotic
DCs also
induce TGF-beta1 secretion in the mediastinal lymph nodes, which results in expansion of Foxp3 ( + ) T ( regs )
Zheng et al., Parasite Immunol 2010
(Malaria) :
In contrast, susceptible BALB/c mice produced more plasmacytoid ( CD11c ( + ) CD45R/B220 ( + ) ) and less mature
DCs , resulting in high
levels of IL-10 and
TGF-beta1