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EGFR — SOCS1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Flowers et al., J Immunol 2004
:
Tkip also inhibited epidermal growth factor receptor autophosphorylation, consistent with the fact that
epidermal growth factor receptor is
regulated by
SOCS-1 and SOCS-3, similar to JAK2
Lee et al., Mol Cancer Ther 2006
(Carcinoma, Squamous Cell...) :
Epigenetic modification of
SOCS-1 differentially regulates STAT3 activation in
response to interleukin-6 receptor and
epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas ... Suppressor of cytokine signaling-1 ( SOCS-1 ) has been implicated recently in the negative regulation of IL-6R/Janus activated kinase ( JAK ) -mediated activation of STAT3, suggesting that
SOCS-1 could
affect alternative activation of STAT3 by
EGFR , IL-6R, and associated kinases ... We investigated whether epigenetic modification of
SOCS-1 affects STAT3 activation in
response to IL-6R-,
EGFR- , JAK-, or mitogen activated protein kinase/extracellular signal regulated kinase kinase ( MEK ) -mediated signal activation
Wang et al., Breast Cancer Res 2008
(Breast Neoplasms) :
Since epidermal growth factor receptor (EGFR), like S100A7, is often expressed in estrogen receptor-alpha negative ( ERalpha- ) breast cancer, we set out to investigate the
role of
Jab1 in mediating
EGFR signaling, another facet of the ERalpha- phenotype