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TP53 — TRIM26
Text-mined interactions from Literome
Arima et al., Int J Mol Med 2002
(Carcinoma, Hepatocellular...) :
These results suggest that HBX interacts with p53 to up-regulate AFP gene transcription probably by restoration of the
p53 mediated repression of the
AFP promotor activity
Li et al., World J Gastroenterol 2004
(Carcinoma, Hepatocellular...) :
Western blot assay also demonstrated that
AFP promoted the expression of mutative
p53 and p21(ras) proteins, and the increased rate of those proteins was 13.0 %, 39.9 %, and 70.9 %, as well as 35.2 %, 102.6 %, and 46.8 % at 6, 12, and 24 h, respectively, as compared with the control
Lee et al., Mol Cell Biol 1999
(Carcinoma, Hepatocellular...) :
HNF-3 protein activates while
p53 represses
AFP transcription through sequence-specific binding within the previously identified AFP developmental repressor domain