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EGR1 — MAPK7
Text-mined interactions from Literome
Bernal-Mizrachi et al., J Biol Chem 2000
:
Pharmacological inhibition of the
Egr-1 induction by H89 ( 48 % ) and calmidazolium ( 35 % ), but not by
mitogen activated protein kinase/extracellular signal regulated kinase kinase 1 and 2 or phosphatidylinositol 3-kinase inhibitors, implied that protein kinase A and Ca ( 2+ ) /calmodulin pathways are involved
Bea et al., Circ Res 2003
(MAP Kinase Signaling System) :
Furthermore, C pneumoniae stimulated phosphorylation of ERK1/2 and Elk-1 and pharmacological inhibition of
mitogen activated protein kinase activity
reduced the expression of TF and
Egr-1
Jones et al., J Cell Physiol 2003
(Hyperoxia) :
MEK inhibitor PD98059, but not inhibitors of p38
MAPK or PI3-kinase pathway,
prevented Egr-1 induction by hyperoxia
Fujita et al., J Clin Invest 2004
(Ischemia...) :
In vitro, hypoxia/reoxygenation mediated induction of
Egr-1 in MPs was
suppressed by inhibition of PKCbeta, ERK1/2, and JNK, but not by inhibition of p38
MAPK
Chen et al., J Cell Biochem 2004
:
Egr-1 is
activated by 17beta-estradiol in MCF-7 cells by
mitogen activated protein kinase dependent phosphorylation of ELK-1
Buchwalter et al., Mol Cell Biol 2005
:
They form ternary complexes with serum response factor (SRF) on serum response elements of immediate early genes such as c-fos and
egr-1 and mediate
responses to growth factors and
mitogen activated protein kinase signaling
Mishra et al., Proc Natl Acad Sci U S A 2006
(Anoxia...) :
In this study we tested the hypothesis that inhibition of
mitogen activated protein kinase dependent
Egr-1 expression may be pivotal in CO-mediated ischemic protection
Ke et al., J Biol Chem 2006
(Lymphoma, B-Cell...) :
Promoter truncation experiments suggested that several serum response elements are required for
MAPK mediated
egr-1 expression ... Unlike ERK and JNK, p38
MAPK reduces constitutive expression of
egr-1
Yasuoka et al., Am J Pathol 2009
(Pulmonary Fibrosis) :
Egr-1 was up-regulated by IGFBP-5 in a
MAPK dependent manner and bound to nuclear IGFBP-5
Allen et al., Toxicol Appl Pharmacol 2010
(MAP Kinase Signaling System) :
Results from these studies demonstrate that activation of
MAPK signaling is
required for upregulation of
Egr-1 by bile acids in hepatocytes and for upregulation of Egr-1 in the liver during cholestasis
Horita et al., J Comp Neurol 2010
:
Dusp1 is an inactivator of mitogen activated protein kinase ( MAPK ), and
MAPK activates expression of
egr1 , one of the most commonly studied IEGs, as determined in cultured cells
Shen et al., Am J Pathol 2011
(Pulmonary Disease, Chronic Obstructive) :
The accumulation of
EGR-1 and GGPPS was
induced by
MAPK/ERK pathway activation when Beas-2B human bronchial epithelial cells were exposed to cigarette smoke extract (CSE)
Shen et al., J Biol Chem 2011
(Diabetes Mellitus, Type 2...) :
In this report, we found that chronic exposure to hyperinsulinism caused persistent
Erk/MAPK activity in adipocytes and enhanced insulin resistance in an
Egr-1 dependent manner
Haschemi et al., PloS one 2011
(Inflammation) :
In addition to PPAR? SUMOylation, CO-activated p38
MAPK was
responsible for
Egr-1 repression
Iyoda et al., J Biol Chem 2012
(MAP Kinase Signaling System) :
Our data demonstrate that activation of ERK1/2 and JNK, but not p38
MAPK , is
required for LPA induced
Egr-1 expression in smooth muscle cells
Beno et al., J Biol Chem 1995
:
Protein kinase C and
mitogen activated protein kinase are
required for 1,25-dihydroxyvitamin D3-stimulated
Egr induction ... These results suggest that 1 ) D3 stimulates MAPK via a protein kinase C-dependent pathway, 2 ) D3-induced Egr expression can occur via a pathway independent of Ras induced Raf, and 3 ) D3 absolutely
requires MAPK activity for
Egr expression