Korchnak et al., Cell Signal 2009
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Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase ( MAP3K ) that activates multiple mitogen activated protein kinase ( MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
Cuenda et al., Biochem J 1998
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Here we demonstrate that MLK2 activates SAPK kinase-1 (SKK1)/MAPK kinase 4 ( MKK4 ) and SKK4/MKK7, the two known direct activators of SAPK1/JNK ( both in transfection studies and in vitro )