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EPHB2 — ICAM1
Text-mined interactions from Literome
Lee et al., J Dermatol Sci 2002
(Behcet Syndrome) :
Specific
MAPK/ERK kinase inhibitor PD98059
inhibited IgM-AECA induced ERK1/2 activities and
ICAM-1 expression on HDMEC at a concentration of 60 microM ...
ERK1/2 are
involved in expression of
ICAM-1 on HDMEC stimulated with IgM-AECA
Walsh et al., Am J Respir Cell Mol Biol 2004
(Neuroblastoma) :
Eosinophil binding to neuronal
ICAM-1 led to a rapid activation of
ERK1/2 in nerve cells
Tsang et al., J Leukoc Biol 2005
(Inflammation...) :
Selective inhibitor of
ERK , PD098059, and c-kit inhibitors, STI571 and PP1,
suppressed the combined SCF and TNF-alpha induced
ICAM-1 expression
Traore et al., J Cell Biochem 2007
(Leukemia, Myeloid) :
Together, these observations demonstrated that TPA, a potent activator of PKC, induces
ICAM-1 expression via a ROS- and
ERK1/2 dependent signaling mechanism in ML-1 cells
Nizamutdinova et al., Int Immunopharmacol 2007
(Atherosclerosis) :
The inhibitory effect of paeonol on
ICAM-1 production might be
mediated by inhibiting p38,
ERK and NF-kappaB signaling pathways, which are involved in TNF-alpha induced ICAM-1 production
Tsou et al., Toxicol Appl Pharmacol 2007
:
Inhibition of
ERK , JNK, or NF-kappaB
attenuates TNF-alpha induced
ICAM-1 promoter activation and monocyte-endothelial monolayer binding
Tyagi et al., Mol Cell Biochem 2008
(Cardiovascular Diseases) :
In cultured ECs, Fg binding to
intercellular adhesion molecule-1 and to alpha(5)beta(1) integrin,
caused phosphorylation of
ERK
Ishizuka et al., J Pharmacol Exp Ther 2008
:
Inhibition of NF-kappaB activation and inhibition of
ERK1/2 phosphorylation
inhibited 20-HETE induced
ICAM expression
Chae et al., Cell Physiol Biochem 2007
:
PD98059, an inhibitor of
ERK1/2 inhibited the Ang II-induced increase of VCAM-1 but not of
ICAM-1 in the plasma membranes
Pazdrak et al., J Immunol 2008
:
Moreover, inhibition of
ICAM-1 expression with either antisense oligonucleotide or an ICAM-1 blocking Ab effectively
inhibited ERK activation and eosinophil survival
Ho et al., Immunobiology 2008
(Inflammation...) :
Selective inhibitors of p38 MAPK ( SB203580 ), JNK ( SP600125 ) and
ERK ( PD98059 ) could
suppress TNF-alpha induced CCL2 and
ICAM-1 expression, while only p38 MAPK and ERK inhibitors could suppress TNF-alpha induced VCAM-1 expression
Yang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010
(HIV Infections...) :
p-ERK inhibitor PD98059 almost completely
blocked the Nef up-regulation of the p-ERK and
ICAM-1
Zhao et al., Invest Ophthalmol Vis Sci 2010
(Graves Ophthalmopathy...) :
Inhibition of the
ERK1/2 , p38, JNK, and NF-kappaB pathways
blocked CD40L induced
ICAM-1 secretion
Yang et al., J Cell Physiol 2010
(Arthritis, Rheumatoid) :
These results suggest that in human RASFs, activation of
ERK , JNK, AP-1, and NF-kappaB are
essential for IL-1beta induced
ICAM-1 expression and leukocyte adhesion
Kim et al., J Ethnopharmacol 2011
:
These results suggest that WEHE
induces ICAM-1 expression in human monocytes through
ERK- and ROS dependent signaling pathways, resulting in the subsequent activations of NF-?B, AP-1, SP-1, and STAT-1 transcription factors
Vitiello et al., Microbiol Immunol 2011
:
Using two potent and selective inhibitors of MEK activation by Raf-1 ( PD-098059 ) and p38 ( SB-203580 ), it was also demonstrated that both
ERK1/2 and p38 pathways
play key roles in the production of IL-6 as well as in
ICAM-1 , VCAM-1 and E-selectin expression by Hib porin
Watanabe et al., Acta Med Okayama 2011
(Diabetes Mellitus, Experimental...) :
Expression of
ICAM-1 was significantly
attenuated by inhibitors of
ERK , p38 and JNK ... We conclude that activation of
ERK1/2 , p38 and JNK cascades may be
involved in
ICAM-1 expression in glomerular endothelial cells under diabetic conditions
Abdala-Valencia et al., PloS one 2012
:
Interestingly, d-a-tocopherol inhibited
ICAM-1 activation of PKCa but not the upstream signal
ERK1/2
Zhong et al., Biochem Biophys Res Commun 2012
(MAP Kinase Signaling System) :
Omentin, NF-kB inhibitor ( BAY11-7082 ) and
ERK inhibitor ( PD98059 )
reduced the up-regulation of
ICAM-1 and VCAM-1 induced by TNF-a
Sun et al., J Atheroscler Thromb 2012
(Disease Models, Animal...) :
HDL isolated from ELKO, ELTg, and WT mice inhibited expression of
intercellular adhesion molecule-1 , angiotensin II-induced
activation of
Erk , and growth of cultured vascular smooth muscle cells, whereas EL expression itself did not affect cell migration or growth.Conclusion : EL expression modulates vascular remodeling as well as plasma HDL-C levels