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EPHB2 — MED1
Text-mined interactions from Literome
Hoshi et al., J Biol Chem 2000
:
The phosphorylation of
ERK1/2 was rapidly
induced by
TRAP and bFGF but not by TNF-alpha
Wang et al., J Biol Chem 2002
:
Mediator role of platelet derived growth factor and
ERK
Pandey et al., Mol Cell Biol 2005
:
Importantly, we found that
ERK phosphorylation significantly
increases the stability and half-life of
TRAP220/Med1 in vivo and correlates with increased thyroid hormone receptor dependent transcription
Zheng et al., J Neurosci Res 2009
:
Surprisingly, BAPTA-AM did not block ERK activation, indicating that [ Ca ( 2+ ) ] ( i ) and Ras-Raf-MAPK are not coupled, and the activation of
ERK alone is not
sufficient to up-regulate
Arc transcription
Panja et al., J Biol Chem 2009
:
These results support a dominant
role for
ERK-MNK signaling in control of translational initiation and
Arc synthesis during LTP consolidation in the dentate gyrus
Kumar et al., J Biol Chem 2012
(Synaptic Transmission) :
Mechanistically, intracellular mGluR5 mediated
Arc induction is
dependent upon extracellular and intracellular Ca ( 2+ ) and
ERK1/2 as well as calmodulin dependent kinases as known chelators, inhibitors, and a dominant negative Ca ( 2+ ) /calmodulin dependent protein kinase II construct block Arc increases