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HIF1A — PGF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Patel et al., Blood 2008
:
PlGF increased binding of
HIF-1 alpha to the ET-1 and ET-BR promoters ; this effect was abrogated with mutation of hypoxia response elements in the promoter regions and HIF-1 alpha siRNA and confirmed by chromatin immunoprecipitation analysis
Liu et al., J Cell Biochem 2008
:
However, unlike the effects of hypoxia, this
PGF2alpha induced normoxic increase in
HIF-1alpha is not mediated by an increase in the stability of the HIF-1alpha polypeptide, rather we find that PGF2alpha selectively increases the expression of the alternatively spliced HIF-1alpha I.1 mRNA isoform
Patel et al., Blood 2009
(Anemia, Sickle Cell...) :
PlGF also
increased HIF-1alpha binding to the HRE in the FLAP promoter
Patel et al., J Biol Chem 2010
(Anemia, Sickle Cell...) :
The binding of Egr-1 to HIF-1alpha promoter was corroborated by electrophoretic mobility shift assay and chromatin immunoprecipitation assay, which showed increased Egr-1 binding to the
HIF-1alpha promoter in
response to
PlGF stimulation ... These studies provide a novel mechanism for
PlGF mediated regulation of
HIF-1alpha via Egr-1, which results in increased FLAP expression