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PNKP — XRCC6

Pathways - manually collected, often from reviews:

• NCI Pathway Database DNA-PK pathway in nonhomologous end joining: PNKP (PNKP) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV/PNKP complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4-PNKP) (modification, collaborate)
  Koch et al., EMBO J 2004, Williams et al., Biochem Cell Biol 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database DNA-PK pathway in nonhomologous end joining: PNKP (PNKP) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4) (modification, collaborate)
  Koch et al., EMBO J 2004, Williams et al., Biochem Cell Biol 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database DNA-PK pathway in nonhomologous end joining: Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV/PNKP complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4-PNKP) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4) (modification, collaborate)
  Koch et al., EMBO J 2004, Williams et al., Biochem Cell Biol 2005
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: XRCC6 — PNKP (physical association, affinity chromatography technology) Koch et al., EMBO J 2004

Text-mined interactions from Literome

Lu et al., Nucleic Acids Res 2010 : Thus, XRCC1 can stimulate PNKP by two independent mechanisms
Zolner et al., Nucleic Acids Res 2011 : Ionizing radiation ( IR ) -induced phosphorylation of cellular PNKP on S114 was ATM dependent, whereas phosphorylation of PNKP on S126 required both ATM and DNA-PK