◀ Back to IL12A
ANXA6 — IL12A
Text-mined interactions from Literome
Mullins et al., J Immunol 1999
(Sarcoma, Experimental) :
In contrast, paclitaxel significantly
enhanced both normal host and TBH Mphi IL-12
p70 production in vitro, although TBH Mphi
IL-12 production was lower than that of similarly treated normal host Mphis
Campbell et al., Eur J Immunol 2000
:
IFN-gamma priming augmented Gal-lectin induced
IL-12 mRNA expression independent of TNF-alpha and IL-1beta, and was
required for IL-12
p70 protein production from macrophages and human peripheral blood mononuclear cells
Schmitt et al., J Immunol 2000
:
We suggest that by suppressing DC/Mphi
IL-12p70 secretion while
promoting IL-12p40 homodimer secretion, UV exposure preferentially suppress the activation of Th1 cells, thereby suppressing Th-1 cell-driven inflammatory immune reactions
Walter et al., J Exp Med 2001
(Asthma...) :
Epithelial
IL-12 was also inducible during paramyxoviral bronchitis, but in this case, initial IL-12
p70 expression was
followed by 75-fold greater expression of IL-12 p40 ( as monomer and homodimer )
Grumont et al., J Exp Med 2001
:
Here we show that in CD8 ( + ) dendritic cells, major producers of IL-12
p70 , the Rel/nuclear factor (NF)-kappaB signaling pathway is
necessary for the induction of
IL-12 in response to microbial stimuli
Taoufik et al., Eur J Immunol 2001
:
IL-12p70 and, more effectively, the combination of IL-12p70 and IFN-gamma,
induced IL-12p40 mRNA expression and bioactive
IL-12p70 production
Heystek et al., Clin Immunol 2003
:
We demonstrate that IFNalpha/beta enhance
IL-12p70 production by immature DCs but
inhibit IL-12p70 production by mature DCs
Khan et al., Blood 2006
:
We now provide evidence that hydrogen peroxide ( H2O2 ), a major component of ROSs, inhibits interleukin-12 (IL-12) p40 and
IL-12 p70 induction in murine macrophages and catalase pretreatment prevents H2O2 mediated down-regulation of IL-12
Mahieu et al., Pediatr Crit Care Med 2005
(Respiratory Insufficiency) :
Pathogen induced excessive production of the proinflammatory cytokine TNF-alpha and lack of antibacterial
IL-12 p 70 response in the TA are associated with increased neonatal mortality among ventilated preterm infants
Yanagihori et al., J Invest Dermatol 2006
(Behcet Syndrome...) :
As assessed by semiquantitative reverse transcription-PCR and ELISA, stimulation with Streptococcal antigens specifically increased expression of IL-12 p40 mRNA and protein, in conjunction with
IL-12 p70 induction , in peripheral blood mononuclear cells from heterozygous patients
Oishi et al., Cytokine 2006
:
The rhG-CSF induced a pre-PHx downregulation of the
IL-12p70 protein levels, while also
promoting the post-PHx reduction of the protein levels of
IL-12p70 and IFN-gamma
Olleros et al., Immunology 2007
(Granuloma...) :
Interleukin (IL)-12p40 , a subunit of IL-12p70 and IL-23, has previously been shown to
inhibit IL-12p70 activity and interferon-gamma (IFN-gamma) production
Hensler et al., J Gen Virol 2009
:
We detected expression of interleukin (IL)-6, tumour necrosis factor (TNF)-alpha, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, RANTES and IL-12p40 from 2 to 6 h post-infection, and these peaked by 15-24 h. Expression of these factors decreased 24-48 h post-infection, with the exception of TNF-alpha which remained high throughout the entire 72 h. Interestingly, while
IL-12p40 expression increased post-infection, bioactive
IL-12p70 was not
detected in the supernatants
Jana et al., Glia 2009
(MAP Kinase Signaling System) :
This study was undertaken to investigate underlying mechanisms required for IL-12 p40 ( 2 ) - and
IL-12 p70 induced expression of iNOS in microglia ... In contrast, both IL-12R beta 1 and IL-12R beta 2 were involved for
IL-12 p70 induced microglial expression of iNOS
Gulliver et al., Am J Respir Cell Mol Biol 2011
(Asthma) :
The B(1)R agonist Lda-BK was not chemotactic for hMo-DCs matured using LPS, TNF-a + IL-1ß, or CD40 ligand, but Lda-BK enhanced the secretion of
IL-12p70 and
inhibited the secretion of
IL-12p40 by mature hMo-DCs
McBerry et al., J Immunol 2012
(Disease Models, Animal...) :
p38 MAPK activation and
IL-12p70 production was more robust from TFF2 ( -/- ) CD8+ DC compared with WT CD8+ DC and treatment of WT DC with rTFF2
suppressed TLR induced
IL-12/23p40 production
Fowler et al., Immunol Cell Biol 2013
:
We found that Vd2 cells are indirectly activated by BCG in an
interleukin (IL)-12p70 dependent manner, and that DC production of the
IL-12p70 responsible for Vd2 cell activation requires Toll-like receptor 2/4 ligands from BCG and interferon ( IFN ) -? from memory CD4 T cells
Heinzel et al., J Immunol 1996
(Endotoxemia) :
Pretreatment of IFN-gamma 0/0 mice with recombinant mouse IFN-gamma ( rIFN-gamma ) enhanced circulating TNF-alpha by as much as sixfold, but serum IL-12 p40 and
IL-12 p70 responses increased by only twofold or less
von Stebut et al., J Exp Med 1998
(Leishmaniasis, Cutaneous) :
Parasite internalization was associated with activation manifested by upregulation of major histocompatibility complex ( MHC ) class I and II surface antigens, increased expression of costimulatory molecules ( CD40, CD54, CD80, and CD86 ), and
interleukin (IL)-12 p40 release within 18 h. L. major
induced IL-12
p70 release by DC required interferon gamma and prolonged ( 72 h ) incubation
Isler et al., Am J Respir Cell Mol Biol 1999
:
However, IL-12
p70 was released when the autocrine production of IL-10 was neutralized by IL-10 blocking antibody, and
IL-12 p40 production
increased