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A2M — IL6
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Fennekohl et al., Hepatology 2000
(Acute-Phase Reaction) :
In IL-6 treated hepatocytes PGE ( 2 ) in turn attenuated the
IL-6 induced
alpha(2)-macroglobulin formation via a cyclic adenosine monophosphate ( cAMP ) -dependent signal chain
Bode et al., J Immunol 2001
:
The inhibitory effect of IL-1 beta on
IL-6 induced
alpha 2-macroglobulin expression is due to activation of NF-kappa B ... In this study, it is analyzed how IL-1beta inhibits
IL-6 induced transcriptional activation of the
alpha(2)-macroglobulin promoter ... Accordingly, cotransfection of the NF-kappaB subunits p50 or p65 themselves inhibited
activation of the
alpha(2)-macroglobulin promoter by
IL-6 ... Most interestingly, at least one functional NF-kappaB consensus site is essential for the
IL-6 induced transcriptional activation of the
alpha(2)-macroglobulin promoter
Bode et al., Biol Chem 2001
(Carcinoma, Hepatocellular) :
In this study we show that activation of p38MAPK by IL-6 acts as an inhibitory signal on
IL-6 mediated
activation of STAT and the
alpha2-macroglobulin promoter
Kortylewski et al., J Biol Chem 2003
:
The transient expression of constitutively active Akt inhibited the
IL-6 dependent activity of the
alpha(2)-macroglobulin promoter in HepG2 cells, whereas expression of an inactive mutant of phosphatidylinositol dependent kinase 1 had the opposite effect
Strauss et al., Lab Invest 1992
(Alzheimer Disease) :
In cultured human cells of neurogenic origin ( SH-SY5Y neuroblastoma cells ),
alpha 2-M synthesis could be strongly
induced by the inflammatory cytokine
interleukin-6 (IL-6) indicating that human alpha 2-M behaves as an acute-phase protein in the nervous system
Ganter et al., FEBS Lett 1991
(Alzheimer Disease...) :
Cultured human neuronal ( SH-SY5Y neuroblastoma ) cells synthesize and secrete the potent protease inhibitor
alpha 2-macroglobulin (a2M) upon
stimulation with
interleukin-6 (IL-6) indicating that alpha 2-macroglobulin behaves as an acute-phase protein in the human central nervous system
Brechner et al., Mol Biol Med 1991
:
Transcription of the
alpha 2-macroglobulin gene (alpha 2M) in rat hepatocytes is strongly
induced during acute inflammations by
interleukin 6 (IL6)
Kino et al., J Allergy Clin Immunol 2007
:
TB-2-081 suppressed
IL-6 induced mRNA expression of alpha1-acid glycoprotein,
alpha2-macroglobulin , and beta-fibrinogen in and secretion of the C-reactive protein by rat primary hepatocytes
Kino et al., Eur J Clin Invest 2007
(Acute-Phase Reaction...) :
The compound also suppressed
interleukin-6 induced mRNA expression of alpha2-acid glycoprotein, beta-fibrinogen and
alpha2-macroglobulin in and the secretion of C-reactive protein by rat primary hepatocytes
Toussaint et al., Toxicol In Vitro 1993
:
LPS and
IL-6 ( but only in the presence of hydrocortisone )
increased the secretion of
alpha(2)-macroglobulin ( alpha(2)M ) in rat hepatocytes
Bauer et al., FEBS Lett 1985
:
Murine
interleukin 1
stimulates alpha 2-macroglobulin synthesis in rat hepatocyte primary cultures
Andus et al., Eur J Biochem 1988
:
The
stimulation of
alpha 2-macroglobulin and cysteine proteinase inhibitor synthesis by
interleukin-6 was inhibited by interleukin-1 beta in a dose dependent manner ... The inhibition of N-glycosylation by tunicamycin abolished the
effect of
interleukin-6 on the secretion of
alpha 2-macroglobulin , indicating a possible role of interleukin-6 on N-glycosylation
Matsuda et al., J Immunol 1989
:
alpha 2M did not
inhibit IL-6 activity or its binding to homologous receptor
Kunz et al., Nucleic Acids Res 1989
:
Deletion analyses have shown that the sequences between -852 and -777 as well as between -404 and -165 relative to the cap site, contain regulatory elements involved in the
interleukin-6 dependent
induction of the
alpha 2-macroglobulin gene
Bereta et al., Int J Biochem 1989
:
3. Supernatants from rat peritoneal macrophages and IL-6/IFN-beta
2/BSF-2 obtained from four different laboratories similarly
stimulated synthesis of fibrinogen, alpha 1-cysteine proteinase inhibitor and
alpha 2-macroglobulin , as well as [ 14C ] -accumulation in cultured hepatocytes
Higuchi et al., Gene 1994
:
These results strongly suggested that
IL-6 and LIF are
involved in
alpha 2M induction in the brain, as in the case of the liver
Koj et al., Int J Biochem Cell Biol 1995
(Liver Neoplasms, Experimental) :
HGF enhanced
IL-6 induced synthesis of
alpha-2-macroglobulin but reduced synthesis of C3 complement and alpha-1-acid glycoprotein
Warburton et al., FEBS Lett 1993
:
Interleukin-1 beta,
interleukin-6 and transforming growth factor-beta synergize with hydrocortisone,
increasing the synthesis of
alpha 2-macroglobulin 2- to 4-fold, although they have no effect in the absence of hydrocortisone
Kawser et al., Clin Sci (Lond) 1998
(Disease Models, Animal...) :
Stimulation of hepatic stellate cells with
interleukin-6 at 5 days
caused a significant increase in
alpha2-macroglobulin expression as did exposure to Kupffer-cell conditioned medium
Guillonneau et al., Biochim Biophys Acta 1999
:
Hepatocyte differentiation of WIF-B cells includes a high capacity of
interleukin-6 mediated induction of alpha 1-acid glycoprotein and
alpha 2-macroglobulin