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RAC1 — S1PR2

Text-mined interactions from Literome

Takuwa et al., Biochim Biophys Acta 2002 : Consistent with this, Edg1 and Edg3, and Edg5 regulate the activity of the Rho family GTPase Rac positively and negatively, respectively ... Edg5 mediated Rac inhibition involves stimulation of Rac-GTPase activating protein (GAP) activity, rather than inhibition of Rac-guanine nucleotide exchange factor (GEF) activity
Sugimoto et al., Mol Cell Biol 2003 : Specific inhibition of endogenous Galpha12 and Galpha13, but not of Galphaq, by expression of respective C-terminal peptides abolished S1P2 mediated inhibition of Rac , membrane ruffling, and migration, as well as stimulation of Rho and stress fiber formation ... Overexpression of Galphai, by contrast, specifically antagonized S1P2 mediated inhibition of Rac and migration
Inoki et al., Biochem Biophys Res Commun 2006 : These observations indicate that in contrast to S1P(1) and S1P(3), S1P(2) negatively regulates endothelial morphogenesis and angiogenesis most likely through down regulating Rac
Takuwa et al., Biochim Biophys Acta 2008 (Ischemia) : By contrast, S1P2 , is expressed in high levels on vascular smooth muscle cells ( VSMCs ) and certain types of tumor cells, inhibiting Rac and cell migration via a G ( 12/13 ) -and Rho dependent mechanism
Malchinkhuu et al., Mol Biol Cell 2009 (Glioma) : ISO induced suppression of the migration of glioma cells occurs via beta ( 2 ) -adrenergic receptor/cAMP/Epac/Rap1B/inhibition of Rac, whereas S1P has been shown to suppress the migration of the cells through S1P(2) receptor/Rho mediated down-regulation of Rac1
Takuwa et al., American journal of cancer research 2011 : S1PR1 and S1PR3 mediate directed cell migration toward S1P through coupling to G ( i ) and activating Rac , a Rho family small G protein essential for cell migration ... In sharp contrast, S1PR2 mediates S1P inhibition of Rac at the site downstream of G ( 12/13 ) -mediated Rho activation, thus identified as the first G protein coupled receptor that negatively regulates Rac and cell migration
Loh et al., PloS one 2012 (Muscular Dystrophy, Duchenne) : Pharmacological SPL inhibition increased muscle S1P levels, improved mdx muscle regeneration and enhanced SC proliferation via S1P receptor 2 (S1PR2) dependent inhibition of Rac1 , thereby activating Signal Transducer and Activator of Transcription 3 ( STAT3 ), a central player in inflammatory signaling