Gene interactions and pathways from curated databases and text-mining

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IL10 — SP1

Text-mined interactions from Literome

Tone et al., J Immunol 2000 : The requirement for Sp1 and Sp3 in transcription of IL-10 was confirmed using Drosophila SL2 cells, which lack endogenous Sp factors ... These results suggest that the transcription of IL-10 is positively regulated by both Sp1 and Sp3
Ikeda et al., J Leukoc Biol 2002 : Furthermore, IL-10 suppressed lipopolysaccharide (LPS) induced NF-kappaB binding but not Sp-1
Liu et al., J Immunol 2003 : These results suggested that the interaction between Sp1 and C/EBPbeta and delta induced by LPS cooperatively activated expression of the IL-10 gene
Khadaroo et al., Shock 2004 (Shock, Hemorrhagic) : Reduced IL-10 transcription was not caused solely by impaired nuclear translocation of STAT3 and Sp1/Sp3 transcription factors because LPS induced nuclear translocation of these factors was augmented by antecedent shock
Gee et al., J Immunol 2007 : Taken together, our results suggest that extracellular HIV-Tat induced IL-10 transcription in primary human monocytes is regulated by CREB-1 and Sp-1 transcription factors through the activation of calmodulin/CaMK-II dependent p38 MAPK
Wang et al., J Biol Chem 1995 : Several other transcription factors including NF-IL-6, AP-1, AP-2, GR, CREB, Oct-1, and Sp-1 are not affected by IL-10