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ICAM1 — SOCS1
Text-mined interactions from Literome
Park et al., Mol Endocrinol 2000
:
Furthermore, overexpression of either
SOCS-1 or SOCS-3 significantly
inhibited the IFN-gamma mediated transactivation of the rat
ICAM-1 ( intercellular adhesion molecule-1 ) promoter
Federici et al., J Immunol 2002
(Dermatitis, Allergic Contact...) :
Furthermore,
SOCS1 and, to a lesser extent, SOCS3
reduced membrane expression of
ICAM-1 and HLA-DR, and release of IFN-gamma-inducible protein-10, monokine induced by IFN-gamma, and monocyte chemoattractant protein-1 by keratinocyte clones promoted by IFN-gamma
Koelsche et al., Mol Immunol 2009
:
Altering the subcellular localization of
SOCS1 by mutating clusters of arginine residues within the NLS did not affect the inhibition of interferon mediated STAT1 tyrosine-phosphorylation, but surprisingly led to impaired inhibitory activity of STAT mediated reporter gene induction and IFN-gamma
induced CD54 regulation