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POLR2E — SKP1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of 11 proteins Gstaiger et al., Science 2003
• MIPS CORUM URI complex (Unconventional prefoldin RPB5 Interactor): URI complex (Unconventional prefoldin RPB5 Interactor) complex (CUL1-PFDN2-POLR2E-URI1-RUVBL1-RUVBL2-SKP1-SKP2-STAP1) Gstaiger et al., Science 2003
• IRef Corum Interaction: Complex of 19 proteins (association, molecular sieving) Gstaiger et al., Science 2003

Text-mined interactions from Literome

Djouder et al., Mol Cell 2007 : Growth factor stimulation induces disassembly of URI/PP1gamma complexes through S6K1 mediated phosphorylation of URI at serine 371
Revai et al., Pediatr Infect Dis J 2008 (Hearing Disorders...) : Upper respiratory tract infections (URI) likely lead to acute otitis media (AOM) by causing Eustachian tube dysfunction which creates negative middle ear pressure
Eilebrecht et al., Nucleic Acids Res 2011 : The highly abundant and essential 7SK ncRNA has been shown to negatively regulate RNA Polymerase II transcription by inactivating the positive transcription elongation factor b ( P-TEFb ) in cellular and Tat dependent HIV transcription
Mita et al., Mol Cell Biol 2011 (Prostatic Neoplasms) : Repression of AR-mediated transcription is achieved, in part, by URI binding and regulation of androgen receptor trapped clone 27 ( Art-27 ), a previously characterized AR corepressor
Conaway et al., Cell Mol Biol Res 1993 : Here we describe the properties of SIII as well as its role in regulating the activity of the RNA polymerase II elongation complex