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IFI27 — IL2

Text-mined interactions from Literome

Wells et al., J Immunol 2000 : We find that this anergic state is associated with defects in both TCR coupled activation of the p42/44 mitogen activated protein kinase ( extracellular signal related kinase 1/2 ) and IL-2 mediated down-regulation of the cell cycle inhibitor p27kip1
Asai et al., J Immunol 2002 (Calcium Signaling...) : We demonstrate that the hyporesponsive state of the CD4 T cells was maintained by a selective impairment in the TCR induced calcium/NFAT signaling pathway and in the IL-2R induced degradation of p27 ( kip1 ) and cell cycle progression
Li et al., Blood 2005 : IL-2 induced sustained increase of cyclin E and cyclin A and prevented up-regulation of p27kip1
Gesbert et al., Int Immunol 2005 : In CD4 lymphocytes, IL-2 does not affect p27 ( kip1 ) expression
Charvet et al., J Immunol 2006 : Importantly, IL-2 induced p27 kip1 down-regulation and cyclin D3 up-regulation and FOXO1 phosphorylation were similar in Vav1 ( -/- ) and wild-type T lymphoblasts, indicating that defective FOXO1 phosphorylation and p27 kip1 and cyclin D3 expression do not result from deficient IL-2 signaling in the absence of Vav1
Ohata et al., Biol Blood Marrow Transplant 2011 (Graft vs Host Disease) : Similar to the effect of MPA on T cells, MPA inhibited the down-regulation of p27 on NK cells induced by the incubation of NK cells in the presence of IL-2
Wagner et al., J Immunol 1998 : Taken together, our findings suggest that cyclin D3, cdk6, and p27 play key roles in IL-2- , IL-4-, and IL-10 mediated human B cell proliferation