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GNA11 — HTR2A

Pathways - manually collected, often from reviews:

• KEGG Gap junction: HTR2A/HTR2B/HTR2C → GNA11/GNAQ (protein-protein, activation)
• KEGG Calcium signaling pathway: ADRA1A/ADRA1B/ADRA1D/AGTR1/AVPR1A/AVPR1B/BDKRB1/BDKRB2/CCKAR/CCKBR/CHRM1/CHRM2/CHRM3/CYSLTR1/CYSLTR2/EDNRA/EDNRB/F2R/GRM1/GRM5/GRPR/HRH1/HTR2A/HTR2B/HTR2C/LHCGR/LTB4R2/NTSR1/OXTR/PTAFR/PTGER1/PTGER3/PTGFR/TACR1/TACR2/TACR3/TBXA2R/TRHR → GNA11/GNA14/GNA15/GNAQ (protein-protein, activation)
• Reactome Reaction: HTR2A → GNA11 (indirect_complex) Rubio et al., Genomics 1999, Dowal et al., J Biol Chem 2006, Amatruda et al., Proc Natl Acad Sci U S A 1991, Ferguson et al., J Biol Chem 1986, Chen et al., Biochim Biophys Acta 1996
• Reactome Reaction: HTR2A → GNA11 (reaction) Rubio et al., Genomics 1999, Dowal et al., J Biol Chem 2006, Lambert et al., Science signaling 2008, Amatruda et al., Proc Natl Acad Sci U S A 1991, Ferguson et al., J Biol Chem 1986, Chen et al., Biochim Biophys Acta 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: GNA11 — HTR2A (in vivo) Raymond et al., Pharmacol Ther 2001*
• IRef Ophid Interaction: GNA11 — HTR2A (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Shi et al., Mol Pharmacol 2007 : Phosphorylation of Galpha11 protein contributes to agonist induced desensitization of 5-HT2A receptor signaling ... These data suggest that phosphorylation of Galpha11 protein by PKC and CaMK contributes to agonist induced homologous desensitization of 5-HT2A receptor signaling as well as heterologous desensitization
Shi et al., J Pharmacol Exp Ther 2007 : The receptor binding experiments suggest that phosphorylation of Galpha11 on serine 154 reduces coupling of 5-HT2A receptors, whereas DOI causes down-regulation of 5-HT2A receptors in addition to the phosphorylation induced uncoupling of Galpha11 to 5-HT2A receptors