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Li et al., Cardiovasc Res 2003 : In this process, ox-LDL induced activation of mitogen activated protein kinase ( MAPK p42/44 ) played an important role, since pretreatment of HCAECs with the MAPK p42/44 inhibitor ( PD98059, 10 microM ) inhibited MAPK activation and subsequently attenuated the expression of ACE ( P < 0.01 vs. ox-LDL alone )
Bustamante et al., Cell Mol Biol Incl Cyto Enzymol 2007 : Furthermore, oxLDL and H2O2 but not native LDL strongly enhanced phosphorylation of JNK, p38MAPK and p42/44MAPK
Sun et al., Cardiovasc Res 2009 (Atherosclerosis...) : Cell culture experiments revealed that RAGE mediated oxidative LDL induced activation of p42/44 mitogen activated protein kinases and oxidative stress in macrophages
Bassa et al., J Am Soc Nephrol 1998 (Arteriosclerosis) : This study examined the role of LDL and its oxidatively modified variants ( mildly oxidatively modified LDL [ mm-LDL ] and oxidatively modified LDL [ ox-LDL ] ) on the activation of mesangial cell p42 mitogen activated protein kinase ( MAP kinase ), a key intracellular signaling mechanism associated with cell proliferation