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CD46 — IL10

Text-mined interactions from Literome

Olszyna et al., J Infect Dis 2000 (Endotoxemia) : Sixteen healthy subjects were intravenously injected with lipopolysaccharide (LPS), once with placebo and once with recombinant human interleukin (IL)-10 ( 25 microgram/kg ), to determine the effect of IL-10 on LPS induced production of macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and monocyte chemoattractant protein (MCP)-1
Marie et al., Nat Immunol 2002 (Dermatitis, Contact...) : We found that engagement of CD46-1 or CD46-2 differentially affected CD8 ( + ) T cell cytotoxicity, CD4 ( + ) T cell proliferation, interleukin 2 (IL-2) and IL-10 production as well as tyrosine phosphorylation of Vav in T lymphocytes
Sánchez et al., Eur J Immunol 2004 : The effect of CD46 on IL-10 secretion did not require additional costimuli like anti-CD28 antibodies or phorbol esters
Jones et al., J Immunol 2009 : Neither the genetic absence of IL-4, IL-4Ralpha chain, STAT-6, IFN-gamma, or IL-12p40 nor mAb blockade of IFN-gamma, IL-3, IL-4, IL-5, IL-6, IL-10 , IL-13, IL-17A, IL-12p40, or IL-12p40Rbeta1 before Ag challenge in WT mice reduces the pulmonary MCp increase
Bayraktar et al., Am J Reprod Immunol 2009 : Interestingly, IL-10 down-regulated LTA mediated MCP1 induction, but not that mediated by LPS
Su et al., Clinical and vaccine immunology : CVI 2010 (Tuberculosis, Pulmonary) : The levels of expression of TNF-alpha, MCP-1 , IFN-gamma, and IL-1beta were decreased ; and the level of IL-10 increased in early responders
Cardone et al., Clin Exp Immunol 2011 (Immune Complex Diseases) : However, in the last 10 years, it has become apparent that CD46 is also heavily involved in a new and somewhat surprising functional aspect of the complement system : the down-modulation of adaptive T helper type 1 ( Th1 ) immune responses by regulating the production of interferon ( IFN ) -? versus interleukin (IL)-10 within these cells