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JAK2 — SHC1

Pathways - manually collected, often from reviews:

• BioCarta il 3 signaling pathway: IL-3/IL-3R-alpha/IL-3R-beta/JAK2 complex (JAK2-CSF2RB-IL3RA-IL3) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA) → SHIP (INPP5D) (modification, collaborate) Bone et al., Cell Signal 2000, Damen et al., Proc Natl Acad Sci U S A 1996, Lioubin et al., Genes Dev 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-IL3-IL3RA) (modification, collaborate)
  Bone et al., Cell Signal 2000, Damen et al., Proc Natl Acad Sci U S A 1996, Lioubin et al., Genes Dev 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: SHIP (INPP5D) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-IL3-IL3RA) (modification, collaborate)
  Bone et al., Cell Signal 2000, Damen et al., Proc Natl Acad Sci U S A 1996, Lioubin et al., Genes Dev 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: None → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) (modification, collaborate)
  Ramshaw et al., Blood 2007
  Evidence: mutant phenotype
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) → None (modification, activates) Ramshaw et al., Blood 2007
  Evidence: mutant phenotype
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) (modification, collaborate)
  Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA) → GRB2/GAB2 complex (GRB2-GAB2) (modification, collaborate)
  Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) → GRB2/GAB2 complex (GRB2-GAB2) (modification, collaborate)
  Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) (modification, collaborate)
  Guthridge et al., EMBO J 2006, Dorsch et al., Biochem Biophys Res Commun 1994, Inhorn et al., Proc Natl Acad Sci U S A 1995, Lanfrancone et al., Oncogene 1995, Itoh et al., J Biol Chem 1996, Pratt et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → SHC (SHC1) (modification, collaborate) Guthridge et al., EMBO J 2006, Dorsch et al., Biochem Biophys Res Commun 1994, Inhorn et al., Proc Natl Acad Sci U S A 1995, Lanfrancone et al., Oncogene 1995, Itoh et al., J Biol Chem 1996, Pratt et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → SHC (SHC1) (modification, collaborate) Guthridge et al., EMBO J 2006, Dorsch et al., Biochem Biophys Res Commun 1994, Inhorn et al., Proc Natl Acad Sci U S A 1995, Lanfrancone et al., Oncogene 1995, Itoh et al., J Biol Chem 1996, Pratt et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1) (modification, collaborate)
  Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) (modification, collaborate)
  Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC/PI3K complex (CSF2RB-JAK2-YWHAZ-SHC1-PIK3CA-PIK3R1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) (modification, collaborate)
  Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC/PI3K complex (CSF2RB-JAK2-YWHAZ-SHC1-PIK3CA-PIK3R1-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → None (modification, activates) Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → None (modification, activates) Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GRB2/GAB2 complex (GRB2-GAB2) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database GMCSF-mediated signaling events: GRB2/GAB2 complex (GRB2-GAB2) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA) (modification, collaborate)
  Bone et al., Cell Signal 2000
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA) → SHC (SHC1) (modification, collaborate) Bone et al., Cell Signal 2000
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA) → SHC (SHC1) (modification, collaborate) Bone et al., Cell Signal 2000
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) → SHC (SHC1) (modification, collaborate) Barry et al., J Biol Chem 2009
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ complex (CSF2RB-JAK2-YWHAZ-CSF2-CSF2RA) (modification, collaborate)
  Barry et al., J Biol Chem 2009
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: SHC (SHC1) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ complex (CSF2RB-JAK2-YWHAZ-CSF2-CSF2RA) (modification, collaborate)
  Barry et al., J Biol Chem 2009
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) (modification, collaborate)
  Ramshaw et al., Blood 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → SHIP (INPP5D) (modification, collaborate) Ramshaw et al., Blood 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) → SHIP (INPP5D) (modification, collaborate) Ramshaw et al., Blood 2007
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: JAK2 → SHC1 (indirect_complex)
• Reactome Reaction: JAK2 → SHC1 (reaction) Gu et al., Mol Cell Biol 2000, Pratt et al., J Biol Chem 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: JAK2 — SHC1 (direct interaction, pull down) Giordano et al., J Immunol 1997*
• IRef Biogrid Interaction: JAK2 — SHC1 (direct interaction, pull down) VanderKuur et al., J Biol Chem 1995*
• IRef Hprd Interaction: SHC1 — JAK2 (in vitro) VanderKuur et al., J Biol Chem 1995*, Giordano et al., J Immunol 1997*
• IRef Hprd Interaction: SHC1 — JAK2 (in vivo) VanderKuur et al., J Biol Chem 1995*, Giordano et al., J Immunol 1997*
• IRef Ophid Interaction: SHC1 — JAK2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Ho et al., Blood 2002 : TEL-JAK2 expression in Ba/F3 cells results in constitutive association and tyrosine phosphorylation of Shc and Ship-1 and, consequently, recruitment of Grb2 to TEL-JAK2
He et al., J Biol Chem 1995 : Together, these studies indicate that Jak2 , in part, may mediate the EPO induced phosphorylation of Shc
Watanabe et al., J Biol Chem 1996 : Further analyses of the role of JAK2 in c-fos gene activation in BA/F3 cells expressing hGMR revealed that delta JAK2 inhibited hGM-CSF induced phosphorylation of Shc and protein tyrosine phosphatase 1D
Mohi et al., Mol Biol Cell 1998 : Conversely, activation of the chimeric Jak2 induced neither phosphorylation of Shc or SHP-2 nor activation of the c-fos promoter
Thirone et al., Endocrinology 1999 : Growth hormone stimulates the tyrosine kinase activity of JAK2 and induces tyrosine phosphorylation of insulin receptor substrates and Shc in rat tissues