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JAK2 — SLC9A1

Text-mined interactions from Literome

Garnovskaya et al., Biochemistry 2003 : Activation of NHE-1 was blocked by inhibitors of phospholipase C, CaM, and Jak2 but not by pertussis toxin or inhibitors of protein kinase C. Immunoprecipitation/immunoblot studies showed that 5-HT and Ang II induce phosphorylation of Jak2 and induce the formation of signal transduction complexes that included Jak2, CaM, and NHE-1 ... Thus, mitogen induced activation of NHE-1 in VSMC is dependent upon elevated intracellular Ca ( 2+ ) and is mediated by the Jak2 dependent tyrosine phosphorylation of CaM and subsequent increased binding of CaM to NHE-1 , similar to the pathway previously described for the bradykinin B ( 2 ) receptor in inner medullary collecting duct cells of the kidney [ Mukhin, Y. V., et al. ( 2001 ) J. Biol. Chem. 276, 17339-17346 ]
Coaxum et al., Biochim Biophys Acta 2009 : Furthermore, pharmacological inhibitors of Janus kinase ( Jak2 ) and calmodulin (CaM) attenuated EGF induced NHE-1 activity
Zhou et al., J Cell Physiol 2013 : Full activation of NHE1 by decreased cell volume in 2-cell mouse embryos required the activity of the tyrosine kinase Janus kinase 2 (Jak2), since NHE1 activation was inhibited by the general tyrosine kinase inhibitor genistein, several selective inhibitors of Jak2, and dominant negative Jak2 expressed in 2-cell embryos