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JAK2 — TPO

Text-mined interactions from Literome

Yang et al., Blood 1999 : In addition, hG-CSF induced phosphorylation of STAT3 but not Jak2 or STAT5, while TPO induced phosphorylation of both
Wang et al., Blood 2000 : Previous studies indicated that Janus kinase ( JAK ) and its substrates mediate the effects of TPO on cellular proliferation and survival
Iijima et al., Leukemia 2000 (Leukemia, Lymphoid...) : Triggering of these cell lines by TPO transiently up-regulated tyrosine phosphorylation of JAK-2 and Shc, indicating that their receptor is functional
Lannutti et al., Oncogene 2006 (Thrombocytosis) : Mechanistic studies revealed that TPO stimulation of MKs from lyn ( -/- ) mice did not affect phosphorylation of Janus kinase 2 (JAK2) , signal transducer and activator of transcription ( STAT ) 3, STAT5, or MAP kinase kinase ( MEK )
Baker et al., Cardiovasc Res 2008 (Myocardial Infarction...) : Tpo activated JAK-2 ( Janus kinase-2 ) and p44 MAPK ( mitogen activated protein kinase ) during reperfusion but not prior to ischaemia
Kanaji et al., Eur J Haematol 2008 (Thrombocytopenia) : Although no mutations were identified in MPL, Mpl protein was absent in the platelets and TPO induced phosphorylation of the Janus tyrosine kinase 2 (Jak2) was not detected
Hitchcock et al., Blood 2008 : After Tpo stimulation, internalization was greatly reduced in c-Mpl Y ( 78 ) F and c-Mpl Y ( 8+78 ) F, and these cell lines also exhibited increased proliferation and increased strength and duration of Jak2 , STAT5, AKT, and ERK1/2 activation in response to Tpo
Kuter et al., Int J Hematol 2013 : TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production
Tortolani et al., Blood 1995 (Leukemia) : TPO also induced activation of JAK2 phosphotransferase activity in vitro
Pallard et al., EMBO J 1995 (Leukemia, Megakaryoblastic, Acute) : We demonstrated that TPO activates the kinase JAK2 and a STAT5-like transcriptional factor but not STAT1, STAT2, STAT3 or STAT4, in a very rapid and transient manner
Nagata et al., Leukemia 1997 : Study on signal transduction through Mp1 revealed that Tpo induces activation of JAK2 and Tyk2, which in turn activate STAT1, STAT3 and STAT5
Leven et al., Blood Cells Mol Dis 1997 : Studies on protein phosphorylation revealed that IL6, but not TPO , stimulated phosphorylation of JAK1, JAK2 and MAP kinase