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ADM — GRAP2
Text-mined interactions from Literome
Parameswaran et al., Eur J Pharmacol 1999
:
Associated with the anti-proliferative and apoptotic effects,
adrenomedullin also
causes a decrease in extracellular signal regulated kinase2 ( ERK2 ) and an increase in cJun N-terminal kinase 1 ( JNK1 ) and
P38 mitogen activated protein kinase ( P38 MAPK ) activities ... SB203580 significantly reversed the effects of
adrenomedullin on [ 3H ] thymidine incorporation and cytoplasmic DNA fragmentation, and
inhibited only
P38 MAPK activity ... Wortmannin also inhibited
adrenomedullin stimulated
P38 MAPK activity without affecting ERK2 and JNK1 activities
Shi et al., Di Yi Jun Yi Da Xue Xue Bao 2005
:
Adm contents of the treatment groups were comparable with that of the control group ( P < 0.05 ), and the secretion of
Adm could be
inhibited by the inhibitor of extracellular signal regulated protein kinases ( PD098059 ),
p38 kinase inhibitor ( SB202190 ), calmodulin inhibitor ( W7 ) and Ca ( 2+ ) inhibitor ( nicardipine ) ( P < 0.05 ), but calcineurin inhibitor and protein kinase C inhibitor ( H7 ) had no such effect ( P > 0.05 )
Liu et al., Chin Med J (Engl) 2005
:
Western blot analysis showed that
ADM did not change the expression of t-MAPKs but
increased p-SAPK/JNK and
p-P38MAPK levels and decreased p-ERK level