◀ Back to NOTCH1
MAML2 — NOTCH1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Notch-mediated HES/HEY network:
TWIST1 (TWIST1)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(transcription, inhibits)
Ohtsuka et al., EMBO J 1999, Kurooka et al., J Biol Chem 2000, Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Jarriault et al., Nature 1995, Nishimura et al., Genomics 1998, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, reporter gene
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NCoR/HDAC1 complex (RBPJ-NCOR1_NCOR2-HDAC1)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
p300 (EP300)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
NCoR (NCOR1/NCOR2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
HDAC1 (HDAC1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
MAML1-2 (MAML1/MAML2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
MAML1-2 (MAML1/MAML2)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
p300 (EP300)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(modification, collaborate)
Oswald et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
p300 (EP300)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Oswald et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Oswald et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
p300 (EP300)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(modification, collaborate)
Oswald et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
p300 (EP300)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Oswald et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Oswald et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
p300 (EP300)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
SHARP (SPEN)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
SHARP/RBPJ complex (SPEN-RBPJ)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
MAML1-2 (MAML1/MAML2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
MAML1-2 (MAML1/MAML2)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NCoR/HDAC1 complex (RBPJ-NCOR1_NCOR2-HDAC1)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(transcription, inhibits)
Ohtsuka et al., EMBO J 1999, Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Jarriault et al., Nature 1995, Nishimura et al., Genomics 1998, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, reporter gene
-
NCI Pathway Database Notch signaling pathway:
SHARP (SPEN)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
SHARP/RBPJ complex (SPEN-RBPJ)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
MAML1-2 (MAML1/MAML2)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
MAML1-2 (MAML1/MAML2)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NCoR/HDAC1 complex (RBPJ-NCOR1_NCOR2-HDAC1)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
→
NCoR (NCOR1/NCOR2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
→
HDAC1 (HDAC1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
→
MAML1-2 (MAML1/MAML2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
MAML1-2 (MAML1/MAML2)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
HES1 (HES1)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(transcription, inhibits)
Ohtsuka et al., EMBO J 1999, Castella et al., Mol Cell Biol 2000, Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Fryer et al., Mol Cell 2004, Jarriault et al., Nature 1995, Nishimura et al., Genomics 1998
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
SHARP/RBPJ complex (SPEN-RBPJ)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(transcription, inhibits)
Ohtsuka et al., EMBO J 1999, Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Jarriault et al., Nature 1995, Nishimura et al., Genomics 1998
Evidence: mutant phenotype, reporter gene
-
Reactome Reaction:
NOTCH1
→
MAML2
(reaction)
Fryer et al., Genes Dev 2002, Wallberg et al., Mol Cell Biol 2002, Fryer et al., Mol Cell 2004, Nam et al., Cell 2006
-
Reactome Reaction:
NOTCH1
→
MAML2
(direct_complex)
-
Reactome Reaction:
NOTCH1
→
MAML2
(indirect_complex)
Fryer et al., Genes Dev 2002, Wallberg et al., Mol Cell Biol 2002, Nam et al., Cell 2006
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wu et al., Semin Cancer Biol 2004
(Cell Transformation, Neoplastic) :
Here, we review our current understanding of the
roles of the
MAML proteins in
Notch signaling, and their involvement in certain human cancers
Röser et al., Der Pathologe 2005
(Carcinoma, Mucoepidermoid...) :
The altered function of
MAML 2 causes a disruption of
NOTCH signalling which suggests a novel mechanism of tumorigenesis
Maillard et al., J Exp Med 2006
:
These findings indicate that the Notch requirement during the beta-selection checkpoint in vivo is absolute and independent of the pre-TCR, and it depends on transcriptional
activation by
Notch via the
CSL/RBP-J-MAML complex
Köchert et al., Oncogene 2011
(Lymphoma) :
Finally, in line with the essential
role of
MAML proteins for assembly and activity of the
NOTCH transcriptional complex ( NTC ) , we show that MAML derived small-peptide constructs block NOTCH activity and disrupt NTC formation in vitro
Zhang et al., Development 2013
(Hyperplasia...) :
Collectively, these findings indicated that
Maml mediated
Notch signaling plays a pivotal role in the initiation and maintenance of goblet cell differentiation for normal ocular surface morphogenesis and homeostasis through regulation of Klf4 and Klf5