◀ Back to IL11

GFAP — IL11

Text-mined interactions from Literome

Yanagisawa et al., J Neurochem 2000 : This differentiation process is totally dependent on the gp130 mediated signal-transduction pathway involving activation of a latent cytoplasmic transcription factor, STAT3 ( for signal transducer and activator of transcription 3 ), because ( a ) IL-11 induced astrocyte differentiation is not observed when neuroepithelial cells prepared from gp130-deficient mice were used, ( b ) stimulation of neuroepithelial cells by IL-11 rapidly induces tyrosine-phosphorylation of STAT3, and ( c ) transfection of neuroepithelial cells with a dominant negative form of STAT3 inhibits IL-11 induced activation of the GFAP gene promoter ... We have further identified, in the GFAP promoter region, a STAT3 site at which nucleotide substitutions almost completely abolished the IL-11 induced GFAP promoter activation
DeLeo et al., Eur J Pain 1997 : Immunohistochemistry was used to examine spinal localization of the cytokines, interleukin (IL)-6 , IL-10 and glial activation ( OX-42 for microglia and anti-glial fibrillary acidic protein for astrocytes )