◀ Back to CDK9
CDK9 — MYLIP
Text-mined interactions from Literome
Lu et al., Cancer Res 2011
(Nasopharyngeal Neoplasms) :
Mechanistic investigations revealed that
miR-26a suppressed the expression of c-myc, the cyclin D3 and E2, and the
cyclin dependent kinase CDK4 and CDK6 while enhancing the expression of CDK inhibitors p14(ARF) and p21 ( CIP1 ) in an EZH2 dependent manner
Yamamura et al., Carcinogenesis 2012
(Carcinoma, Renal Cell...) :
miR-34a was also found to
repress the
c-Myc-P-TEFb transcription elongation complex, indicating one of the mechanisms by which miR-34a has profound effects on cellular functions
Maki et al., Anticancer Res 2012
(Mesothelioma...) :
miR-34b/c inhibited expression of cyclin-D1,
cyclin dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly ( ADP-ribose ) polymerase ( cPARP ) and cleaved caspase-3 after irradiation
Giglio et al., J Cell Physiol 2013
:
In this report we describe that miR-24 directly targets p27 ( Kip1 ) and p16(Ink4a) in primary keratinocyte and in different cancer derived cell lines promoting their proliferation, suggesting that
miR-24 is
involved in
cyclin dependent kinase inhibitors post-transcriptional regulation and that upregulation of miR-24 may play a role in carcinogenesis