UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to ERBB2

ERBB2 — PLCD4

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: ERBB2 → PLCD4 (increases, ERBB2 Activity) Leung et al., Molecular cancer 2004 *
Evidence: Overexpression of PLCdelta4 selectively activates protein kinase C-phi and upregulates the expression of epidermal growth factor receptors EGFR/erbB1 and HER2/erbB2, leading to constitutive activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway in MCF-7 cells.