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EPHB2 — IRF6
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Monick et al., J Immunol 1999
:
LPS induced
ERK kinase activation was inhibited by tricyclodecan-9-yl xanthogenate ( D609 ), a relatively specific inhibitor of PC-PLC
Arbabi et al., J Surg Res 1999
:
In addition, HTS and
LPS induce activation of
ERK which is required for PGI2 production
Tominaga et al., Biochim Biophys Acta 1999
:
Although a monosaccharide lipid A analog, GLA-58, was able to stimulate macrophages to activate ERK proteins without cytokine production, pretreatment of macrophages with this compound suppressed both
LPS stimulated activation of
ERK and cytokine production
Vittimberga et al., J Surg Res 1999
:
LPS stimulated activation of
ERK and SAPK/JNK was inhibited by NaSal pretreatment
van der Bruggen et al., Infect Immun 1999
:
Ro 09-2210 completely prevented
LPS induced
ERK1 and ERK2 activation
Nolan et al., Surgery 1999
:
LPS inhibited PMN apoptosis and
activated p38 and
ERK in a dose- and time dependent fashion
Yang et al., J Biol Chem 2000
:
When MD-2, a protein associated with the extracellular domain of TLR4, was expressed in these cells, there was a marked increase in Elk-1 activity as well as
ERK , JNK, and p38 MAP kinase phosphorylation in
response to
LPS
Kim et al., Brain Res 2000
(Glioma) :
Furthermore,
LPS plus CHX
enhanced phosphorylation of
ERK , p38, and CREB in a synergistic manner
Monick et al., J Immunol 2000
:
Kinase activity assays showed that
LPS activates PKC zeta, mitogen activated protein/ERK kinase ( MEK, the upstream activator of ERK ), and
ERK ... We found that a peptide specific for PKC zeta partially blocked
activation of both MEK and
ERK by
LPS
Heagy et al., J Trauma 2000
(Inflammation...) :
Pretreatment of murine macrophages with LPS induces LPS-tolerance, with inhibition of
LPS stimulated activation of kinases (
ERK1/2 and p38 ) and diminished release of tumor necrosis factor (TNF)
Dumitru et al., Cell 2000
(MAP Kinase Signaling System...) :
LPS stimulation of peritoneal macrophages from these mice did not
activate MEK1, ERK1, and
ERK2 but did activate JNK, p38 MAPK, and NF-kappaB
Bonner et al., Infect Immun 2001
:
We found that
LPS activated
ERK 1 and 2 in cells of both adults and newborns and that activation was plasma dependent ( maximal at > or =5 % ) through LPS binding protein ... Although fibronectin in plasma is required for LPS mediated priming of neutrophils of adults assessed by fMLP triggered oxidative burst, it was not required for
LPS mediated activation of
ERK 1 and 2 ... While Western blotting showed that 100 microM PD 98059 completely inhibited
LPS mediated
ERK activation, oxidative response to fMLP by a chemiluminescence assay revealed that the same concentration inhibited the LPS primed oxidative burst by only 40 % ... We conclude that in neutrophils,
LPS mediated activation of
ERK 1 and 2 requires plasma and that this activation is not dependent on fibronectin
Klein et al., Cell Signal 2001
(MAP Kinase Signaling System) :
LPS , fMLP, and LTB ( 4 )
stimulated similar levels of
ERK and Akt activation
Yi et al., Int Immunol 2001
:
Although CpG DNA at the higher concentration slightly enhanced
LPS mediated phosphorylation of
ERK , it did not alter the LPS mediated activation of c-Jun N-terminal kinase and p38
Watters et al., J Biol Chem 2002
:
Although
LPS potently
stimulates ERK activation in RAW 264.7 macrophages, it does not activate ERK-1/-2 in BV-2 microglia ... Moreover, antagonism of the MEK/ERK pathway potentiates LPS stimulated nitric oxide production, suggesting that
LPS stimulated
ERK activation can exert inhibitory effects in macrophage-like cells
Zhang et al., Chin J Traumatol 2001
(Endotoxemia...) :
In mKC, LPS treatment resulted in transient and rapid increase of kinase activity of ERK1/2 that phosphorylated their specific substrate ELK-1, with maximal value at 30 minutes and a return near to baseline within 2 hours, and
LPS induced
ERK1/2 activity from LPS concentration of 10 pg/ml to the top activity at 100 ng/ml
Barbosa de Oliveira et al., Braz J Med Biol Res 2002
:
Finally, there was a cell density dependent
LPS effect on protein tyrosine phosphatase (PTP) and
ERK1/ERK2 mitogen activated protein ( MAP ) kinase activities
Zirngibl et al., Mol Cell Biol 2002
:
Bone marrow derived Fps/Fes-null macrophages showed no defects in granulocyte-macrophage colony stimulating factor-, interleukin 6 (IL-6)-, or IL-3 induced activation of signal transducer and activator of transcription 3 ( Stat3 ) and Stat5A or
LPS induced degradation of I kappa B or activation of p38, Jnk,
Erk , or Akt
Takeda et al., Invest Ophthalmol Vis Sci 2002
(Uveitis) :
The present study suggests that
LPS stimulation
activates ERK in Müller cells, whereas the total amount of ERK is unchanged ... Because the
LPS induced
p-ERK level was reduced by Dex treatment, its expression seems to be associated with ocular inflammatory stimulus
Shi et al., Am J Physiol Cell Physiol 2002
:
Using a chloramphenicol acetyltransferase reporter gene linked to the Egr-1 promoter, we show that
LPS increased Egr-1 promoter activity via an
ERK1/2 dependent mechanism
Rao et al., J Toxicol Environ Health 2002
(MAP Kinase Signaling System) :
In the three cell lines examined, all three families of MAPKs were activated upon stimulation with either lipopolysaccharide (LPS) or LPS plus interferon-gamma ; in contrast, only
ERK1/2 was activated in primary rat alveolar macrophages upon
stimulation with
LPS
Li et al., Endocrinology 2002
:
Nevertheless,
LPS induced degradation of IkappaB and phosphorylation of
ERK in osteoclasts as well as in osteoclast precursors
Woo et al., Mol Cells 2002
(MAP Kinase Signaling System) :
Our results showed that
LPS induced the activation of
ERK and p38 MAP kinase in a Rac dependent manner, suggesting a mediatory role of Rac1 in LPS signaling to MAPKs stimulation
Xagorari et al., Br J Pharmacol 2002
:
Pretreatment of RAW 264.7 with luteolin inhibited the
LPS induced
ERK1/2 and p38, but not JNK1/2, phosphorylation, and blocked the LPS induced TNF-alpha release
Jiang et al., Shock 2002
(Inflammation...) :
These data indicate that
LPS stimulation, although not inducing any change in protein expression,
results in rapid activation of
ERK1/2 , p54JNK, and p38 kinases in KCs, and that they may have different importance in the regulation of pro- and anti-inflammatory responses by LPS stimulated KCs
Jiang et al., Zhonghua Yi Xue Za Zhi 2002
(MAP Kinase Signaling System) :
ERK1 , JNK1, and p38 MAPKs were transiently
activated by
LPS
Heagy et al., Shock 2003
(MAP Kinase Signaling System) :
LPS induced endotoxin-tolerance with a significant inhibition of
LPS stimulated TNF secretion and less p44/p42
ERK kinase activation ...
LPS stimulated p44/p42
ERK kinase activation and TNF release were diminished whether or not anti-CD14 antibody was present during LPS pretreatment ...
LPS stimulated TNF secretion and p44/p42
ERK kinase activation require the presence of serum and are inhibited by anti-CD14 antibody
Lai et al., J Immunol 2003
:
Thus,
LPS induction of MMP-1 production by monocytes is
regulated by both
ERK1/2 and p38, whereas MMP-9 stimulation occurred mainly through the ERK1/2 pathway
Kikuchi et al., J Dent Res 2003
:
These findings indicate that Cot/Tpl2 is essential for
LPS induced
ERK activation and RANKL induction in osteoblasts
Eliopoulos et al., EMBO J 2003
:
Macrophages from Tpl2 knockout ( Tpl2 ( -/- ) ) mice exhibit a defect in
ERK activation by
lipopolysaccharide (LPS)
Soldatos et al., Insect Biochem Mol Biol 2003
:
The response of hemocytes to these stimuli denoted that hemocyte
ERK is evidently
stimulated by at least an
LPS receptor and via an integrin mediated process
Xie et al., J Immunol 2003
:
Furthermore,
LPS up-regulated the secretion of IL-1beta, IL-6, IL-8, IL-10, and TNF-alpha ; reduced Ag presentation capacity ; and
inhibited phosphorylation of
ERK , but activated p38, leading to a reduced NF-kappaB activity in treated cells
Kojima et al., Am J Physiol Gastrointest Liver Physiol 2004
(MAP Kinase Signaling System) :
Whereas
LPS stimulated both the p38 and
ERK1/2 but not the stress activated protein kinase/c-Jun NH ( 2 ) -terminal kinase, signaling pathways in the YAMC cells, all three were stimulated in RAW macrophage cells ( in which no LPS induced HSP25 expression was observed )
Huang et al., Nat Immunol 2004
:
Furthermore, MEKK3 is crucial for IL-1- and
LPS induced activation of NF-kappaB and JNK-p38 but not
ERK , indicating that MAPKs are differentially activated during IL-1R-TLR4 signaling
Nishiki et al., Am J Physiol Cell Physiol 2004
(MAP Kinase Signaling System) :
G-CSF did not affect
LPS induced activation of
ERK , p38, JNK, and NF-kappa B, indicating that G-CSF affects the pathway downstream or independently of these signaling molecules
Kesavan et al., J Cell Physiol 2004
:
Bacterial
lipopolysaccharide (LPS) and TNFalpha neither
activate ERK5 nor require MEKK2 for JNK activation, demonstrating specificity of MEKK2 in FGF-2 receptor signaling and control of cytokine gene expression
Serikov et al., J Endotoxin Res 2004
:
The first aim was to determine whether
LPS induces
ERK1/2 activation and changes in epithelial permeability in epithelial cells alone or only in the presence of immune cells
Balaraman et al., Biochem Biophys Res Commun 2004
:
The use of inhibitors selective for ERK ( PD98059 ) and p38 ( SB203580 ) mitogen activated protein ( MAP ) kinase pathway showed that preincubation of cells with either SB203580 or PD98059 did not affect the binding activity of IRF-E, suggesting that both p38 and
ERK MAP kinase activation are not
necessary for
IRF-E activation
Weiss et al., Antimicrob Agents Chemother 2004
:
Activation of
ERK1/2 and the 46-kDa p-JNK protein was
enhanced by
LPS and LPS-PMA and was significantly inhibited by MXF ( 54 and 42 %, respectively, with MXF at 10 microg/ml )
Cuschieri et al., J Surg Res 2004
:
LPS stimulation
led to the mobilization of TLR4 to lipid rafts followed by phosphorylation and activation of IRAK,
ERK 1/2, p38, and JNK/SAPK
Lee et al., Respir Res 2004
(MAP Kinase Signaling System...) :
SP600125 or PD98059 inhibited
LPS induced phosphorylation of JNK and
ERK , total protein and LDH activity in BAL fluid, and neutrophil influx into the lungs
Choi et al., Arch Pharm Res 2004
:
Tanshinones exerted inhibitory activities on the LPS induced nitric oxide production only when applied concurrently with LPS, and tanshinone-IIA and cryptotanshinone were found to inhibit
LPS induced NF-kappaB mobilization and
extracellular regulated kinase (ERK) activation, respectively
Shinohara et al., J Exp Med 2005
:
The stimulation with
LPS of macrophages from mice lacking Dok-1 or Dok-2
induced elevated
Erk activation, but not the other MAP kinases or NF-kappaB, resulting in hyperproduction of TNF-alpha and nitric oxide ... Forced expression of either adaptor, but not a mutant having a Tyr/Phe substitution, in macrophages inhibited
LPS induced
Erk activation and TNF-alpha production
An et al., Blood 2005
(Inflammation) :
Neither disrupting phosphatase activity nor using the PI-3K pathway inhibitor LY294002 or wortmannin could significantly block SHIP1 mediated inhibition of
LPS induced
ERK1/2 , p38, and JNK activation and TNF-alpha production, demonstrating that SHIP1 inhibits LPS induced activation of MAPKs and cytokine production primarily by a phosphatase activity- and PI-3K independent mechanism
Peng et al., Circulation 2005
(Cardiomyopathies) :
NADH oxidase activation by
LPS increased
ERK1/2 and p38 phosphorylation, and inhibition of ERK1/2 and p38 phosphorylation blocked the effect of NADH oxidase on TNF-alpha expression
Kim et al., Immunopharmacol Immunotoxicol 2005
:
In contrast, mercury alone had no effect on activation of extracellular signal regulated kinase ( ERK ) but inhibited
LPS induced
ERK activation ... Mercury modulates
LPS induced p38 and
ERK activation and downstream TNFalpha and IL-6 expression in mouse liver
Brun et al., Am J Physiol Gastrointest Liver Physiol 2005
(Inflammation...) :
These LPS mediated effects in HSCs were receptor dependent, because
LPS induced
ERK1 phosphorylation, IL-6, and MCP-1 mRNA and protein level upregulation were significantly less pronounced in HSCs isolated from C3H/HeJ mice lacking Toll-like receptor 4
Yang et al., Am J Physiol Heart Circ Physiol 2005
(Vasculitis) :
Expression of a dominant negative form of TLR4 in human SMC attenuated
LPS induced
ERK1/2 and MCP-1 release
Lee et al., Br J Pharmacol 2005
:
AP-1 promoter activity and p38 MAPK activation but not PKC,
ERK and JNK activation
induced by
LPS were attenuated by oregonin
Han et al., Bioorg Med Chem Lett 2005
:
As expected, the coumarin compounds potently inhibit
LPS induced TNFalpha production and
ERK phosphorylation in THP-1 cells, with the most potent compound having an IC ( 50 ) of 90nM
Gutiérrez-Venegas et al., Life Sci 2006
:
These findings demonstrate that
LPS from A. actinomycetemcomintans
increases rapidly p44 and p42 phosphorylation (
ERK 1 and ERK 2, respectively ) in human gingival fibroblasts
Saito et al., J Pharmacol Sci 2005
:
Activation of
extracellular regulated kinase (ERK) by
LPS was markedly attenuated in both macrophages isolated from in vivo daunorubicin treated rats and those incubated in vitro with daunorubicin at 1 microM
David et al., J Immunol 2005
:
In that pharmacological inhibitors of PI3K inhibited LPS induced activation of p21Ras, but not activation of ERK, we concluded that
LPS induced activation of
ERK occurs through a pathway that is not dependent on the activation of p21Ras
Thakur et al., Am J Physiol Gastrointest Liver Physiol 2006
:
gAcrp suppressed
LPS stimulated
ERK1/2 and p38 phosphorylation as well as IkappaB degradation at 100-1,000 ng/ml in Kupffer cells from both pair- and ethanol fed rats ... However, only
LPS stimulated
ERK1/2 phosphorylation was sensitive to 10 ng/ml gAcrp ... Suppression of
LPS stimulated
ERK1/2 signaling by low concentrations of gAcrp was associated with normalization of TNF-alpha production by Kupffer cells after chronic ethanol exposure
Zhao et al., J Biol Chem 2006
:
IFN-gamma enhanced
lipopolysaccharide (LPS) induced
ERK and JNK phosphorylation but had no effect on LPS induced NF-kappaB activation ... Interestingly, we found that IRF-8-/- macrophages were impaired in the activation of
LPS induced
ERK and JNK and the production of proinflammatory cytokines induced by LPS or IFN-gamma plus LPS
Suh et al., Arch Biochem Biophys 2006
:
The findings herein show that the inhibition of
LPS induced
ERK1/2 activation may be a contributing factor to the main mechanisms by which OC inhibits RAW264.7
Thakur et al., J Leukoc Biol 2006
:
Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells : role of increased reactive oxygen in
LPS stimulated
ERK1/2 activation and TNF-alpha production ... However, only
LPS stimulated
ERK1/2 phosphorylation was inhibited by DPI, which also reduced LPS stimulated TNF-alpha production in Kupffer cells from pair- and ethanol fed rats
Shan et al., Am J Physiol Lung Cell Mol Physiol 2006
(Asthma...) :
Collectively, these data support the novel concept that TLR4 activation in ASM elicits changes in ASM function that are regulated by opposing effects of MAPK signaling, wherein
LPS induced
ERK1/2 activation mediates NF-kappaB dependent proasthmatic-like changes in ASM function, whereas coactivation of p38 MAPK serves to homeostatically downregulate the proasthmatic effects of ERK1/2 activation
Nakamura et al., J Biol Chem 2006
(MAP Kinase Signaling System) :
In Raw 264.7 cells treated with MNSFbeta small interfering RNA ( siRNA )
lipopolysaccharide (LPS) induced
ERK1/2 activation was enhanced and LPS induced JNK and p38 activation was unaffected ... Finally, we found that transfection with MNSFbeta expression construct resulted in a significant inhibition of
LPS induced
ERK activation and TNFalpha production
Yang et al., Mol Immunol 2007
:
Moreover,
LPS activated NFkappaB p65,
ERK1/2 and JNK1/2 and induced their translocation to the nucleus
Liu et al., J Neurosci Res 2006
:
NO had no effect on
LPS stimulated
ERK1/2 and p38 MAPK activation, suggesting that the inhibitory action of NO occurs downstream of MAPK cascades
Prêle et al., Immunology 2006
:
SOCS3 over-expression had no effect on TNF-alpha mRNA levels
induced by
LPS or LPS plus IL-10, or on IL-10 phosphorylation of STAT3, STAT1 and
ERK1/2
Parameswaran et al., J Biol Chem 2006
:
We find that
lipopolysaccharide (LPS) induced
ERK1/2 phosphorylation is significantly enhanced in arrestin-2 and GRK5 knockdown cells ... Taken together, these results suggest that p105 phosphorylation by GRK5 and binding of arrestin-2 negatively regulates
LPS stimulated
ERK activation
Rani et al., Immunobiology 2006
(Disease Models, Animal...) :
LPS induced phosphorylation of
ERK1/2 was also decreased in peritoneal macrophages isolated after haemorrhagic shock
Kogut et al., Mol Immunol 2007
:
The role of Ras activation in
LPS induced stimulation of
ERK1/2 was corroborated when the specific Ras inhibitor, FTI-277, inhibited ERK1/2 activation
Bolon et al., J Cell Physiol 2007
:
We propose that
LPS reduces inter-endothelial electrical coupling via tyrosine-,
ERK1/2- , PKA-, and PKC dependent signaling that targets Cx40
Thorley et al., J Immunol 2007
:
Macrophage ( but not ATII cell ) responses to
LPS required activation of
ERK1/2 and p38 MAPK signaling cascades ; phosphorylated ERK1/2 was constitutively up-regulated in ATII cells
Sherry et al., J Immunol 2007
(Diabetes Mellitus, Type 2) :
LPS dependent stimulation of PI3K activity,
ERK1/2 activation, and p38 kinase activity was greater in PerMphi from db/db mice as compared with db/+ mice
Wu et al., Int Immunopharmacol 2007
:
Ginsenosides inhibited the phosphorylation of c-Jun NH2-terminal kinase (JNK), c-Jun and extracellular signal regulated kinase ( ERK ), The findings herein show that the inhibition of
LPS induced
ERK1/2 and JNK activation may be a contributing factor to the main mechanisms by which ginsenosides inhibits RAW264.7
Toshchakov et al., J Immunol 2007
(MAP Kinase Signaling System) :
TLR4- and TLR2-BBPs also strongly inhibited
LPS induced activation of
ERK
Sánchez-Tilló et al., J Biol Chem 2007
(MAP Kinase Signaling System) :
Lipopolysaccharide (LPS) induces macrophage activation, stops proliferation, and
delays ERK phosphorylation, thereby triggering an inflammatory response
Fan et al., Mol Immunol 2007
(Inflammation) :
Over expression of wild type beta-arrestins 1 and 2 had no effect on
LPS induced
ERK1/2 activation and LPS induced IL-8 production suggesting that endogenous beta-arrestins 1 and 2 are sufficient to mediate maximum ERK 1/2 activity and IL-8 production
Park et al., Int Immunopharmacol 2007
(Inflammation) :
Molecular mechanisms that govern attenuation of the levels of mRNAs and proteins of these cytokines and iNOS revealed that the PC extract inhibited
LPS stimulated phosphorylation of
ERK and activation of NF-kappaB
Li et al., Blood 2007
:
Functional differences between TGF-M-DCs and TGF-GM-DCs included enhanced responses to
LPS induced
ERK , JNK, and P38 activation in TGF-M-DCs and their immune suppressive skewed cytokine release profiles
Hung et al., Pediatr Allergy Immunol 2007
:
LPS induced pp38 and
p-ERK expression of THP-1 monocytic cells was suppressed by ketotifen ... The suppressive effect on MDC and IP-10 may, at least in part, involve the down-regulation of
LPS induced p38 and
ERK-MAPK expression
Gutiérrez-Venegas et al., Int Immunopharmacol 2007
:
Our results showed that
LPS treatment
induces activation of extracellular signal related kinase 1/2 (
ERK1/2 ), p38, and c-jun-NH ( 2 ) -terminal kinase ( JNK )
Robinson et al., Mol Cell Biol 2007
:
LPS activation of
ERK requires TPL-2 release from associated NF-kappaB1 p105, which blocks TPL-2 access to its substrate, the ERK kinase MEK ... TPL-2 ( S400A ) expression also failed to reconstitute
LPS activation of
ERK and induction of TNF in Map3k8 ( -/- ) macrophages, which lack endogenous TPL-2
Hall et al., J Biol Chem 2007
(Arthritis, Rheumatoid...) :
We have developed a series of highly selective and potent Tpl2 inhibitors, and in the present study we have used these inhibitors to demonstrate that the catalytic activity of Tpl2 is required for the
LPS induced activation of MEK and
ERK in primary human monocytes
Ostrowska et al., Biochem Biophys Res Commun 2008
:
Thus, activation of PARs but not stimulation with
LPS leads to
ERK1/2 and JNK mediated production of IL-8
Komura et al., Journal of thrombosis and haemostasis : JTH 2008
:
Pretreatment with KT5720, a protein kinase A inhibitor, reversed the inhibitory effect of AT on the
LPS induced phosphorylation of
ERK1/2
Jung et al., Exp Mol Med 2007
(Inflammation) :
The molecular mechanisms that underlie celastrol mediated attenuation were the inhibition of
LPS induced phosphorylation of
MAPK/ERK1/2 and the DNA binding activity of NF-kappaB in BV-2 cells
Wu et al., Toxicol Appl Pharmacol 2008
:
Additional studies with murine macrophages expressing wild type and mutated TLR4 showed that TLR4 was implicated in
LPS induced
ERK and NFkappaB activation, and CD40 expression
Singru et al., Endocrinology 2008
:
Intracerebroventricular administration of the MAPK inhibitor, PD98059, prevented
LPS induced
ERK1/2 phosphorylation, c-fos activation, and the increase of CRH gene expression in the PVN but had no effect on c-fos activation in brainstem A2-C1/C2 regions ... We conclude that
LPS rapidly
increases the
phospho-ERK1/2 in CRH containing neurons in the PVN and that activation of MAPKs is necessary for LPS induced activation of the hypothalamic-pituitary-adrenal axis
Ou et al., Respirology 2008
:
However,
LPS stimulated expression of p38 and
ERK1/2 in airway epithelium was not affected by roxithromycin
Pace et al., Immunology 2008
:
The
LPS increased the expression of TLR4 and
induced both NF-kappaB and
ERK1/2 activation
Qian et al., Parkinsonism Relat Disord 2007
:
Further studies showed that 10 ( -14 ) M DPI significantly reduced
LPS induced
ERK phosphorylation
Hickey et al., J Leukoc Biol 2008
:
CyaA enhanced
LPS induced phosphorylation of p38 MAPK and
ERK in DC, and inhibitors of p38 MAPK, MEK, or NF-kappaB suppressed IL-10 production in response to LPS and CyaA
Bolon et al., J Cell Physiol 2008
(Sepsis) :
We conclude that
LPS + H/R
initiates tyrosine kinase- and
ERK1/2-sensitive signaling that synergistically reduces inter-endothelial electrical coupling by dephosphorylating PKA-specific serine residues of Cx40
Qian et al., J Immunol 2008
(Inflammation) :
In addition,
LPS induced
ERK phosphorylation and subsequent Ser345 phosphorylation on p47phox were significantly inhibited by TGF-beta1 pretreatment
Kim et al., J Microbiol Biotechnol 2008
(MAP Kinase Signaling System) :
Moreover, PGA1 inhibited
LPS induced
ERK phosphorylation
Sundararaj et al., J Leukoc Biol 2008
:
Simvastatin also inhibited
LPS stimulated
ERK but not p38 MAPK and JNK ... Finally, we showed that the inhibition of
LPS stimulated
ERK activation by simvastatin was reversed by GGPP
Byeon et al., J Ethnopharmacol 2008
(Disease Models, Animal...) :
The blockade of inflammatory mediators by taheebo seemed to be the result of the interruption of extracellular signal related kinase ( ERK ) activation, according to immunoblotting analysis and the NO assay, where
LPS strongly
induced the phosphorylation ( a hallmark of activation ) of
ERK , and U0126, a selective ERK inhibitor, was found to strongly inhibit PGE ( 2 ) production
Park et al., J Biol Chem 2008
:
Treatment with gAcrp decreased
LPS stimulated
ERK1/2 phosphorylation and IkappaB degradation and suppressed the ability of LPS to increase the DNA binding activity of Egr-1 and p65
Pocivavsek et al., Glia 2009
(Inflammation) :
LPS induced both
ERK and JNK activation, whereas EP induced ERK activation, but drastically reduced JNK activation
Dhungana et al., Mol Cell Proteomics 2009
:
Given previous reports of an essential role for proteasomal degradation of IkappaB kinase phosphorylated p105 in
LPS activation of
ERK mitogen activated protein kinase, we tested for a role of rafts in compartmentalization of these events
Tsai et al., Inflammation 2008
:
Furthermore, ATRA suppressed the expression of
LPS stimulated c-Raf, MKK1/2 and
ERK expression of THP-1 cells
Miksa et al., Int J Mol Med 2008
(Inflammation) :
LPS induced phosphorylation of
ERK1/2 , p38 and JNK is more enhanced in RPM compared to TGPM
Zhang et al., Cell Signal 2009
(MAP Kinase Signaling System) :
Lithium also promotes the
activation of Tpl2 and
ERK by the TLR4 ligand
LPS
Finzi et al., J Immunol 2009
(Biliary Tract Neoplasms...) :
LPS induced early phosphorylation of EGFR and
ERK1/2 in both types of cells, which reached maximum levels within 30 min ( first phase )
Kim et al., J Pharmacol Sci 2009
:
As a mechanism of action, MSA inhibited
LPS induced activation of NF-kappaB,
ERK , p38, and JNK, which played pivotal roles in toll-like receptor 4-mediated DC maturation
Lee et al., J Ethnopharmacol 2009
:
Then, BV inhibited
LPS induced expression of PKC-alpha and
MEK/ERK , not p38 and JNK
Li et al., Int Arch Allergy Immunol 2009
:
Inhibition of
ERK , JNK or p38 MAPK
had little discernible effect on
LPS-inducible CRAMP gene expression
Lin et al., Chem Biol Interact 2009
:
LPS- and LTA induced NOS/NO productions were significantly
suppressed by the JNK inhibitor, SP600125, but not by the
ERK inhibitor, PD98059, through a reduction in JNK protein phosphorylation
Wu et al., Br J Pharmacol 2009
:
Effects of tripterine were investigated on endothelial barrier function, inducible nitric oxide synthase (iNOS) expression, nicotinamide adenine dinucleotide phasphate ( NADPH ) oxidase activity, 3-nitrotyrosine formation, protein phosphatase type 2A (PP2A) activity,
activation of
extracellular regulated kinase (ERK) , c-Jun terminal kinase (JNK) and Janus kinase ( Jak2 ), and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [
lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma ...
LPS + IFNgamma
stimulated phosphorylation of
ERK , JNK and Jak2, and degradation of IkappaB, but only Jak2 phosphorylation was sensitive to tripterine ( 50-200 nM )
Nam et al., Can J Physiol Pharmacol 2009
:
In addition, Chunghyuldan significantly decreased
LPS induced phosphorylation of the
ERK1/2 and p38 signaling proteins
Li et al., J Ethnopharmacol 2009
:
LPS induced phosphorylation of
ERK1/2 and p38 were inhibited by TMP
Yang et al., J Immunol 2009
:
Increased LPS induced cytokine expression in the absence of ANXA1 was accompanied by significantly increased
LPS induced activation of
ERK and JNK MAPK and was abrogated by inhibition of either of these pathways
Lacour et al., J Immunotoxicol 2009
:
Moreover, we found that p38MAPK, JNK, and
ERK were
activated by APAP or
LPS alone or in association
Lai et al., J Agric Food Chem 2009
:
We also found that rosmanol suppressed
LPS induced phosphorylation of
ERK1/2 , p38 mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling
Seo et al., Bone 2010
(MAP Kinase Signaling System...) :
LPS induced M-CSF expression is
mediated by
ERK
Kim et al., Biochem Biophys Res Commun 2010
:
In the present study, we confirmed the inhibition of nuclear translocation of activated
p-ERK1/2 and NF-kB p50 in
response to growth stimuli or
LPS in the senescent human diploid fibroblasts
Brandenburg et al., Inflamm Res 2010
(Inflammation) :
SF inhibits
LPS stimulated
ERK1/2 and JNK phosphorylation and thereby inhibits the LPS induced activation of NF-kappaB- and activator protein-1 (AP-1)
Watford et al., J Immunol 2010
(Pneumonia) :
The protein kinase encoded by the Tpl2 proto-oncogene regulates
ERK activation and cytokine gene expression in macrophages in
response to
LPS and TNF-alpha
Wang et al., Lab Invest 2010
(Disease Models, Animal...) :
LPS/GalN mediated phosphorylation of JNK1/2 and
ERK1/2 was differentially regulated in wild-type and PXR-null mice
González-Navajas et al., J Clin Invest 2010
(Colitis...) :
Mechanistically,
LPS stimulation of TLR4 bearing CD4+ T cells
inhibited ERK1/2 activation upon subsequent TCR stimulation via the induction of MAPK phosphatase 3 (MKP-3)
Xuan et al., Cell Physiol Biochem 2010
:
Moreover,
LPS induced phosphorylation of prosurvival kinases Akt and
ERK1/2 was abrogated by thymoquinone
Yoon et al., Food Chem Toxicol 2010
:
AFE inhibited
LPS induced
ERK , JNK, and p38 phosphorylation
Gerilechaogetu et al., Anim Sci J 2009
:
The signaling pathways leading to the
activation of extracellular signal regulated kinase (
ERK ) by phorbol 12-myristate 13-acetate ( PMA ), formyl-methionylleucyl-phenylalanine ( fMLP ) and
lipopolysaccharide (LPS) in chicken heterophils were examined ... These results indicate that the
LPS induced phosphorylation of
ERK in the chicken heterophils is mediated by PLC, PKC and intracellular calcium, and the PMA stimulated phosphorylation is dependent on intracellular calcium ion and PKC
Chao et al., J Agric Food Chem 2010
:
At the same time, honokiol not only inhibited nitric oxide expression in LPS stimulated murine macrophages but also inhibited the
LPS induced phosphorylation of
ERK1/2 , JNK1/2, and p38
Tang et al., Am J Med Sci 2010
(Cell Transformation, Neoplastic...) :
LPS increased the phosphorylation of
ERK1/2 and P38 and activated NF-kappaB
Oh et al., Neurosci Lett 2010
(Inflammation) :
We also showed that oleamide inhibited
LPS induced phosphorylation of Akt, p38 MAPK, and
ERK , activation of PI 3-kinase, and accumulation of reactive oxygen species ( ROS )
Huang et al., J Immunol 2010
:
Blockage of
LPS induced
ERK , JNK, Akt, and NF-kappaB activation contributed to the inhibitory effect of quercetin on DCs
He et al., J Cell Biochem 2010
:
The activation of TLR4 by
LPS modulated the expression of TLRs,
induced the phosphorylation of NF-kappaB, P38, and
ERK42/44 , and up-regulated the gene expression of cytokines IL-8, IFN-alpha, IFN-beta, and TNF-alpha, suggesting EPCs expressed functional TLR4
Hsieh et al., Phytomedicine 2011
(Bone Resorption...) :
On osteoclasts, icariin suppresses LPS mediated activation of the p38 and JNK ; while on the osteoblasts, icariin reduced the
LPS induced activation of
ERK1/2 and I-kappa-B-alpha ( I?Ba ), but increased the activation of p38
Peirce et al., PloS one 2010
:
Moreover,
LPS induced activation of the MAP kinases
ERK and p38 was enhanced in cells over expressing Themis2 whereas the activation of JNK, IRF3 or NF-kappaB p65, was unaffected
Lu et al., Journal of neuroinflammation 2010
(Inflammation) :
Resveratrol had no effect on
LPS stimulated phosphorylation of
ERK1/2 and p38 in microglia and astrocytes, but slightly inhibited LPS stimulated phosphorylation of JNK in astrocytes
Ta et al., Atherosclerosis 2010
:
Results showed that 1nM of alogliptin inhibited
ERK phosphorylation
induced by
lipopolysaccharide (LPS) , a ligand for toll-like receptor (TLR)4, by 91 %
Gorina et al., Glia 2011
:
p38 exerted a strong influence on
LPS induced gene expression by regulating the phosphorylation of Stat1 and the transcriptional activity of NF?B, while JNK regulated the Jak1/Stat1 pathway, and
ERK1/2 controlled the expression of Egr-1 and influenced MyD88 dependent MMP-9 expression
Cho et al., Mol Immunol 2011
:
However, IL-4 did not affect
LPS induced phosphorylation of
ERK and p38
Min et al., Int Immunopharmacol 2011
(Inflammation) :
Withaferin A had no effect on
LPS induced Akt and
ERK phosphorylation, but phosphorylation of p38 and JNK was slightly decreased by withaferin A. Withaferin A significantly inhibited LPS induced STAT1 and STAT3 phosphorylation in a dose dependent manner
Terra et al., Free radical research 2011
(Inflammation...) :
LPS induced
ERK1/2 activation through phosphorylation, which was inhibited by all the compounds tested, the most active being epigallocatechin ( EG ), followed by epigallocatechin gallate ( EGCG ) and C1
Jang et al., Arch Oral Biol 2011
(Inflammation...) :
bPN also inhibited the
LPS stimulated activation of JNK and
ERK signaling, and inhibited the LPS stimulated degradation of I ( K ) B in the RAW264.7 cells
Das et al., J Biol Chem 2011
(Substance Withdrawal Syndrome) :
EMSA revealed a concurrent decrease in consensus binding to transcription factors NF?B, Activator Protein-1, and CCAAT/enhancer binding protein and Western blot analysis demonstrated a significant activation of
LPS induced
ERK1/2 phosphorylation ... Interestingly, although glucocorticoid treatment alone also modulated these transcription factors and ERK1/2 activation, the addition of glucocorticoids to MW samples resulted in a greater than additive reduction in the transcription factors and significant hyperactivation of
LPS induced
ERK1/2 phosphorylation
Kim et al., Evidence-based complementary and alternative medicine : eCAM 2012
:
In addition, Myrrh inhibited
LPS induced
activation of c-jun NH ( 2 ) -terminal kinase ( JNK ) but not of extracellular signal regulated kinase (
ERK ), p38, and nuclear factor-?B
Watts et al., Am J Physiol Cell Physiol 2011
(MAP Kinase Signaling System...) :
LPS induced a rapid ( < 15 min ) and sustained ( up to 60 min ) increase in
ERK phosphorylation in microdissected MTALs that was blocked by PD98059
Küper et al., American journal of physiology. Renal physiology 2012
:
In conclusion, these results propose that
LPS mediates enhanced COX-2 expression in IMCD cells by 1 ) TLR4 mediated activation of the NF-?B signaling pathway, 2 ) TLR4 dependent release of TGF-a with subsequent activation of the EGFR and downstream MAPKs p38 and
ERK1/2 , and 3 ) TLR4 mediated, EGFR independent activation of JNK that negatively regulates NF-?B activation
Shoeb et al., Free Radic Biol Med 2012
(Inflammation) :
Furthermore, benfotiamine prevented the
LPS induced phosphorylation of
ERK1/2 and expression of transcription factors NF-?B and Egr-1
Guindi et al., Cell Immunol 2012
(MAP Kinase Signaling System) :
LPS stimulation
triggered ERK1/2 activation that was sustained in GM/DCs but not in IL-4/DCs
Park et al., PloS one 2011
:
Capric acid had no effects on
LPS induced activation of the NF-?B, JNK,
ERK1/2 , and STAT1 pathways
Zhao et al., PloS one 2012
:
The C-terminal region of p105 is necessary for
LPS induced
ERK activation and it has been suggested that ERK activity inhibits both IFN-ß and IL-12 p40 following LPS stimulation
Soromou et al., Molecules (Basel, Switzerland) 2012
:
The data showed that 7-O-methylnaringenin could downregulate
LPS induced levels of phosphorylation of
ERK1/2 , JNK and I?Ba
Joo et al., Gut and liver 2012
:
LPS induced phosphorylation of
ERK1/2 , JNK, and p38 was inhibited by EGCG
Huang et al., PloS one 2012
(Edema...) :
Inotilone also inhibited
LPS induced
ERK , JNK, and p38 phosphorylation
Fengyang et al., Inflammation 2012
(Inflammation...) :
Western blot analysis showed that stevioside suppressed
LPS induced NF-?B activation, I?Ba degradation, phosphorylation of
ERK , JNK, and P38
Yang et al., Mol Cell Biol 2012
:
The Nfkb1 ( SSAA ) mutation prevented the agonist induced release of TPL-2 from its inhibitor p105, which blocked
activation of
ERK by
lipopolysaccharide (LPS) , tumor necrosis factor (TNF), CpG, tripalmitoyl-Cys-Ser-Lys ( Pam ( 3 ) CSK ), poly ( I · C ), flagellin, and R848
Peng et al., PloS one 2012
:
We show here that DOK3 is a negative regulator of TLR signaling by limiting
LPS induced
ERK activation and cytokine responses in macrophages
Leow-Dyke et al., Journal of neuroinflammation 2012
(Immune System Diseases...) :
In glial cultures,
LPS induced activation of
ERK1/2 , p38 and JNK ... In contrast, in neuronal cultures,
LPS activated JNK but not
ERK1/2 or p38, and the specific JNK inhibitor SP600125 significantly blocked LPS induced KC expression and release
Tang et al., Oncol Res 2012
(Colonic Neoplasms) :
LPS increased phosphorylation of
ERK1/2 and p38 and activated NF-kappaB
Han et al., Immunopharmacol Immunotoxicol 2013
(Inflammation...) :
As a result, CPS inhibited proinflammatory cytokines, iNOS, and COX-2, which is attributed to the suppression of
LPS induced
ERK , JNK, and nuclear factor-?B ( NF-?B ) activation
Hong et al., BMC complementary and alternative medicine 2012
(Inflammation) :
CWE blocked the
LPS induced degradation of I?Ba as well as the
activation of JNK, p38 and
ERK1/2
Lee et al., J Cell Biochem 2013
:
NaHS blocked nicotine and
LPS induced
activation of p38,
ERK , MKP-1, PI3K, PKC, and PKC isoenzymes, and NF-?B
Ren et al., Zhonghua Gan Zang Bing Za Zhi 2012
:
In addition, the phosphorylation levels of ERK and JNK were induced in macrophages at 15 min after LPS stimulation, while the phosphorylation level of p38 MAPK was induced at 1 h ; SB216763 pretreatment suppressed the
LPS stimulated
ERK , JNK and p38 phosphorylation in macrophages
Li et al., Cell Physiol Biochem 2012
(Acute Lung Injury...) :
In freshly isolated alveolar macrophages from wild type and Ksr1-deficient mice,
LPS increased
ERK activation, nuclear translocation of NF?B and expression of inflammatory cytokines and chemokines in a similar pattern ... Inhibition of Src or Raf-1 blocked
LPS induced
ERK activation ... Taken together, these findings indicate that Ksr1 plays a dispensable role in
LPS induced
ERK activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS model
Khan et al., J Ethnopharmacol 2013
(Edema...) :
The
LPS induced activation of p-JNK, p-p38,
p-ERK , and p-Akt was significantly inhibited
Kim et al., Food Chem Toxicol 2013
(Inflammation) :
DPEP inhibited
LPS induced phosphorylation of
ERK , JNK, and p38
Jeong et al., Food Chem Toxicol 2013
:
In addition, PA
inhibited LPS- or TNF-a stimulated ERK1/2 activation by decreasing phosphorylation of
ERK1/2
Terazawa et al., Pharmacol Res 2013
:
The compound 1 inhibited
LPS stimulated
ERK phosphorylation after LPS treatment
Slomiany et al., Inflammopharmacology 2013
:
We show that
ERK activation by the
LPS leads to phosphorylation of the inhibitory ?B kinase-ß ( IKK-ß ) and cytosolic phospholipase A2 (cPLA2), and is reflected in the upsurge in NF-?B nuclear translocation, induction in COX-2 and iNOS expression, and up-regulation in cPLA2 activity
Wu et al., Bioorg Med Chem 2013
(Inflammation...) :
Mechanistically, F35 and F36 dose-dependently prevented
LPS induced NF-?B and
ERK activation
Lee et al., Food Chem Toxicol 2013
:
Further studies revealed that PL suppressed the production of tumor necrosis factor-a (TNF-a) or Interleukin (IL)-6 and
activation of nuclear factor-?B ( NF-?B ) or
extracellular regulated kinases (ERK) 1/2 by
LPS
Chung et al., PloS one 2013
(Inflammation) :
S100A12 reduced serum amyloid A-, but not
LPS induced
ERK1/2 phosphorylation to baseline
Uhde et al., Int Immunol 2013
:
Furthermore, LPS stimulation led to high IL-10 production derived from CD83tg MZ B cells that reacted to
LPS stimulation with enhanced
ERK1/2 activation
Rao et al., PloS one 2013
:
Similarly, low-dose
LPS significantly
inhibited TNF-a, IL-6, ATF4-CHOP pathway, NF-?B pathway, and
ERK1/2 in high-dose LPS stimulated macrophages, whereas IL-10 and cytokine signaling ( SOCS ) -3 suppressor were induced
Gui et al., Mediators Inflamm 2013
(Sepsis) :
Further studies showed that GW405833 inhibits
LPS induced phosphorylation of
ERK1/2 and STAT3 and blocks I ? B a degradation and NF- ? B p65 nuclear translocation in macrophages
Wan et al., J Endocrinol 2013
:
DHT enhanced
LPS induced p38MAPK,
ERK1/2 , and nuclear factor ?B pathway activation, which may contribute to the elevated expression of UCN1
Wang et al., Dig Dis Sci 2013
(Carcinoma, Hepatocellular...) :
LPS-TLR4 induced
activation of
ERK and JNK signaling promotes cell proliferation through regulating Bax translocation to mitochondria
Wu et al., Cell Res 2013
:
Mlkl-deficient MEFs and macrophages were indistinguishable from wild-type cells in their ability to activate NF-?B,
ERK , JNK, and p38 in
response to TNF and
lipopolysaccharides (LPS) , respectively
Han et al., Int Immunopharmacol 2013
:
We found that sauchinone decreased the phosphorylation of p38 MAPK in
lipopolysaccharide (LPS) stimulated murine bone marrow neutrophils, but not
ERK1/2 and JNK
Sato et al., Biochem Biophys Res Commun 1995
:
Western blots showed that DT-5461 suppressed the
LPS induced tyrosine phosphorylation of
p42mapk/ERK2
Geppert et al., Mol Med 1994
:
Measurements of
LPS induced MEK and
ERK2 activity were undertaken in LPS-sensitive and LPS-insensitive cells ... In RAW 264.7 mouse macrophages, both
ERK2 and MEK1 activity are
induced by
LPS treatment
Dziarski et al., J Infect Dis 1996
:
sPGN- and
LPS induced activation of
ERK1 and ERK2, unlike PDB induced activation, was sensitive to inhibition by herbimycin A and insensitive to inhibition by increased intracellular cAMP
Durando et al., J Leukoc Biol 1998
:
Pretreatment with PT inhibited basal and
LPS stimulated , but not PMA stimulated
ERK activation ... LPS pre-exposure resulted in a profound decrease in
LPS stimulated activation of
ERK , but did not affect PMA activation of ERK
Niiro et al., Biochem Biophys Res Commun 1998
:
Interestingly,
LPS induced phosphorylation and activation of
ERK2 was significantly inhibited by IL-4 and IL-10, while that of p38 MAPK was inhibited by IL-10, but not IL-4
Hu et al., J Biol Chem 1998
:
Moreover, the
activation of ERK1 and
ERK2 by
LPS , but not by the phorbol ester, phorbol 12-myristate 13-acetate, is also blocked in RAW 264.7 cells by o-ATP pretreatment