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PTGS2 — TIMP1
Text-mined interactions from Literome
Han et al., Mech Ageing Dev 2004
(Arthritis, Rheumatoid...) :
The selective
COX-2 inhibitor, NS-398, can
inhibit the senescence associated increases of COX-2, PGE ( 2 ), p53 and MMP-1 expression, and the senescence associated decreases of PCNA,
TIMP-1 and procollagen expression
Takaoka et al., Int J Oncol 2006
(Carcinoma...) :
These results indicated that overexpression of
COX-2 elevated tumorigenicity, tumor growth and invasion of human KB carcinoma cells via up-regulated MMP and Rho family small GTPases and
down-regulated TIMP activities
Ramer et al., Biochem Pharmacol 2010
:
Collectively, this data demonstrate a
COX-2 dependent upregulation of
TIMP-1 conferring the antimigratory action of cannabinoids