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EPO — TNF

Text-mined interactions from Literome

Jelkmann et al., Exp Hematol 1999 : Tumor necrosis factor p55 receptor ( TNF-RI ) mediates the in vitro inhibition of hepatic erythropoietin production ... The present study was carried out to find out as to whether the 55 kD ( TNF-RI ) or the 75 kD ( TNF-RII ) receptor is responsible for the TNFalpha induced inhibition of hepatic Epo synthesis
Zhu et al., Zhonghua Xue Ye Xue Za Zhi 2000 (Anemia...) : The effects of TNF alpha and IFN-gamma on cobalt induced erythropoietin production in human hepatic cancer cells ( HepG2 ) were examined ... TNF alpha and IFN-gamma could specifically inhibit cobalt induced Epo production in HepG2 cells, and suppressed normal bone marrow BFU-E and CFU-E growth in a dose dependent manner
Imagawa et al., FASEB J 2003 (Anemia) : However, 15 U/ml IL-1beta, 220 U/ml TNF-alpha , or 10 ( -3 ) M L-NMMA inhibited Epo protein production and promoter activity, respectively ... Addition of 10 microM K-7174 rescued these inhibitions of Epo protein production and promoter activity induced by IL-1beta, TNF-alpha , or L-NMMA, respectively
Zhai et al., Zhonghua Er Ke Za Zhi 2004 (Anemia...) : This study aimed to detect the EPO levels in children 's ACD, to explore the relationship between EPO and tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) and, to evaluate the effect of recombinant human TNF alpha ( rhTNF-alpha ) on EPO gene expression
Chen et al., Exp Cell Res 2004 : Erythropoietin dependent autocrine secretion of tumor necrosis factor-alpha in hematopoietic cells modulates proliferation via MAP kinase -- ERK-1/2 and does not require tyrosine docking sites in the EPO receptor ... The EPO induced , membrane bound form of autocrine TNF-alpha seemed to enhance proliferation of HCD57 and DA3-EPOR cells ; however, the concentration of secreted autocrine/paracrine TNF-alpha was never sufficient to have an effect ... BAF3 cells expressing a mutant EPOR with no cytoplasmic tyrosine residues were capable of triggering EPO dependent TNF-alpha synthesis and secretion, indicating that tyrosine docking sites in the EPOR were not required for EPO dependent TNF-alpha secretion
Lee et al., J Neurochem 2006 (Brain Edema...) : In addition, EPO reduced the mRNA level of TNF-alpha , Fas and Fas-L, as well as the activities of caspase-8, 9 and 3
Fandrey et al., Ann N Y Acad Sci 1991 (Carcinoma, Hepatocellular...) : Interleukin-1 and tumor necrosis factor-alpha inhibit erythropoietin production in vitro ... A dose dependent decrease of up to 60 % in Epo production was induced by interleukin-1 beta, interleukin-1 alpha, and tumor necrosis factor-alpha ( in that order of potency )
Sasaki et al., Spine (Phila Pa 1976) 2011 (Intervertebral Disc Displacement...) : Effects of asialo-erythropoietin on pain related behavior and expression of phosphorylated-p38 map kinase and tumor necrosis factor-alpha induced by application of autologous nucleus pulposus on nerve root in rat ... A-EPO improved pain related behavior and reduced the expression of p-p38 and TNF-a
Cervellini et al., J Biol Regul Homeost Agents 2013 (Necrosis) : Erythropoietin does not affect TNF and IL-6 production directly
Makarova et al., Klin Med (Mosk) 2013 (Coronary Disease...) : In most CHD patients elevated levels of TNF-alpha inhibited hepatic synthesis of EPO
Fandrey et al., Eur J Biochem 1994 (Carcinoma, Hepatocellular...) : Hypoxia induced erythropoietin (Epo) production in vitro is suppressed by interleukin 1 beta (IL-1 beta), tumor necrosis factor alpha (TNF) and phorbol esters
Piéroni et al., Gerontology 1997 (Anemia...) : These findings suggest that systemic TNF alpha or IL-1 beta are not involved in the erythropoietin response to ACD