Gene interactions and pathways from curated databases and text-mining

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MAP2K7 — TNF

Text-mined interactions from Literome

Manna et al., Biochem Pharmacol 1999 : Beta-lapachone also abolished TNF induced activation of AP-1, c-Jun N-terminal kinase, and mitogen activated protein kinase kinase ( MAPKK or MEK )
Manna et al., Oncogene 1999 : gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited TNF induced activation of JNK and mitogen activated protein kinase kinase
Manna et al., J Biol Chem 2000 : hCG abrogated the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase required for NF-kappaB and AP-1, respectively
Manna et al., J Immunol 2000 : Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents, inhibited the TNF induced activation of transcription factor AP-1, and suppressed the TNF induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase
Manna et al., J Immunol 2000 : Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation
Cha et al., J Pharmacol Exp Ther 2006 : The Syk inhibitor also decreased TNFalpha induced mitogen activated protein kinase kinase ( MKK ) 4 phosphorylation but not MKK3 and MKK6 phosphorylation, which is consistent with its selective sparing of p38
Manna et al., J Biol Chem 1998 : In addition, Mn-SOD blocked the TNF mediated activation of activated protein-1, stress activated c-Jun protein kinase, and mitogen activated protein kinase kinase