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BMP2 — SMURF1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database BMP receptor signaling:
SMAD7/SMURF1 complex (SMAD7-SMURF1)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
SMAD7/SMURF1 complex (SMAD7-SMURF1)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
SMAD1 (SMAD1)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
BMP2
→
SMURF1
(reaction)
Ebisawa et al., J Biol Chem 2001, Suzuki et al., J Biol Chem 2002, Murakami et al., Mol Biol Cell 2003
-
Reactome Reaction:
BMP2
→
SMURF1
(indirect_complex)
Ebisawa et al., J Biol Chem 2001, Suzuki et al., J Biol Chem 2002, Murakami et al., Mol Biol Cell 2003
Text-mined interactions from Literome
Murakami et al., Mol Biol Cell 2003
:
Herein, we examined whether
Smurf1 negatively
regulates BMP signaling together with the I-Smads Smad6/7 ...
Smurf1 thus
controls BMP signaling with and without I-Smads through multiple mechanisms
Zhao et al., J Biol Chem 2004
:
To determine the role of Smurf1 in osteoblast differentiation, in the present studies we transfected a Smurf1 expression plasmid into 2T3 osteoblast precursor cells and found that
Smurf1 overexpression
inhibits BMP signaling and osteoblast differentiation
Yamashita et al., Cell 2005
:
However, loss of
Smurf1 does not
affect the canonical Smad mediated intracellular TGFbeta or
BMP signaling ; instead, it leads to accumulation of phosphorylated MEKK2 and activation of the downstream JNK signaling cascade
Alexandrova et al., Dev Biol 2006
:
Smurf1 was initially implicated in
BMP pathway
regulation in embryonic development, but its potential role in vertebrate embryogenesis has yet to be clarified
Cui et al., EMBO J 2011
:
SCFFBXL15
regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase
Smurf1