Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
AKT1
→
PDPK1
(directlyIncreases, PDPK1 Activity, AKT1 Activity)
Evidence: identified four sites (Ser-124, Thr-308, Thr-450, and Ser-473) on Akt1 that are phosphorylated in vivo. Thr-308 and Ser-473 are inducibly phosphorylated after treatment of cells with extracellular stimuli, whereas Ser-124 and Thr-450 appear to be basally phosphorylated The third mechanism by which 3'-phosphorylated phosphoinositides regulate Akt activity is by controlling the accessibility of Akt as a substrate for PDKs. In in vitro reconstitution assays, the binding of PI3,4,5P to the Akt PH do...
OpenBEL Selventa BEL large corpus:
AKT1
→
PDPK1
(directlyIncreases, PDPK1 Activity, AKT1 Activity)
Evidence: PI3K activation results in recruitment of the serine/threonine kinase PDK1, (3-phosphoinositide-dependent kinase 1) to the plasma membrane where PDK1 subsequently phosphorylates and activates AKT