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GH1 — IL6
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
IL6
→
GH1
(decreases)
Evidence: Various animal models of genetically determined insulin resistance and obesity, including ob/ob, db/db mice, as well as fa/fa rats, overexpress TNF-? In humans, TNF-? mRNA and protein expression in fat are low but positively correlate with body adiposity, and decrease in obese subjects after weight loss [26, 27]..
Text-mined interactions from Literome
Fasshauer et al., Horm Metab Res 2003
(Insulin Resistance) :
Interleukin (IL)-6 mRNA expression is
stimulated by insulin, isoproterenol, tumour necrosis factor alpha,
growth hormone , and IL-6 in 3T3-L1 adipocytes
Laing et al., J Appl Physiol 2008
:
EX-C blunted the circulating norepinephrine, cortisol, granulocyte-colony stimulating factor, and
IL-6 response ( P < 0.01 ) but not the plasma epinephrine and serum
growth hormone response
Buzzelli et al., J Trauma 2008
:
Nuclear factor kappaB mediates the inhibitory
effects of
interleukin-1 on
growth hormone-inducible gene expression
Gong et al., Chin Med Sci J 2008
(MAP Kinase Signaling System) :
Mek and p38 MAPK-dependant pathways are involoved in the positive
effect of
interleukin-6 on human
growth hormone gene expression in rat MtT/S somatotroph cells ... To investigate the
effect of
interleukin-6 (IL-6) on the human
growth hormone ( hGH ) gene expression in a rat somatotropic pituitary cell line MtT/S
Nelson et al., Curr Opin Clin Nutr Metab Care 2008
(Critical Illness) :
Music may also increase
growth hormone levels, which can
induce decreased production of cytokines such as
IL-6 by white blood cells
Zhang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2013
:
[
Effect of recombinant human
growth hormone on the secretion of TNF-a and
IL-6 by THP-1 cells and its correlation with the NF-?B pathway ] ... Objective To investigate the
effect of recombinant human
growth hormone ( rhGH ) on the secretion of TNF-a and
IL-6 in THP-1 cells and analyze the correlation between the secretion and NF-?B signaling pathway
Wada et al., Endocrinology 1995
:
Inhibitory
effects of
interleukin-1 on
growth hormone secretion in conscious male rats
Swolin et al., J Clin Endocrinol Metab 1996
:
Growth hormone increases
interleukin-6 produced by human osteoblast-like cells