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IGFBP5 — IL6

Text-mined interactions from Literome

Feliers et al., Br J Haematol 1999 (Multiple Myeloma) : In contrast, IGFBP4 was not regulated in response to IL-6 , TNF-alpha, PDGF BB, bFGF, TGF-beta or the cAMP agonist, forskolin
Franchimont et al., Endocrinology 1997 : We tested the effects of IL-6 in the presence and absence of its soluble receptor ( sIL-6R ) on IGFBP-5 expression in cultures of osteoblast enriched cells from 22-day-old fetal rat calvariae ( Ob cells ) ... In contrast, when IL-6 and sIL-6R were tested in combination, they caused a considerable increase in IGFBP-5 mRNA levels, and IL-6 at 100 ng/ml and sIL-6R at 125 ng/ml increased IGFBP-5 transcripts by 5- to 7-fold after 24 h ... The effect of IL-6 and sIL-6R on IGFBP-5 transcripts was not blocked by indomethacin, but cycloheximide markedly inhibited IGFBP-5 mRNA levels in control and treated cultures ... IL-6 and sIL-6R did not increase intact IGFBP-5 levels in the extracellular matrix and increased IGFBP-5 fragments in the culture medium ... In conclusion, IL-6 , in the presence of sIL-6R, stimulates IGFBP-5 mRNA expression in Ob cells by transcriptional mechanisms, and accelerates the fragmentation of the protein