◀ Back to EGFR

EGFR — FADD

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FADD → Complex of EGFR-FAS (increases, EGFR/FAS Activity, FADD Translocation) Reinehr et al., J Biol Chem 2005*
  Evidence: Activated Yes rapidly associated with the epidermal growth factor receptor (EGFR), which became phosphorylated at Tyr845 and Tyr1173 but not at Tyr1045. Activated EGFR then triggered an AG1478-sensitive CD95-tyrosine phosphorylation, which was a signal for membrane targeting of the EGFR/CD95 complex, subsequent recruitment of Fas-associated death domain and caspase 8, and apoptosis induction. All of these events were significantly blunted by inhibitors of sphingomyelinase, PKCzeta, NADPH oxidase...

Text-mined interactions from Literome

Iwase et al., Oral Oncol 2008 (Carcinoma, Squamous Cell...) : Although EGFR inhibitors did not affect the expression of Fas, the Fas associated death domain protein , or procaspase-8 in OSCC cells, the inhibition downregulated cellular FLICE-inhibitory protein ( c-FLIP )
Lokeshwar et al., Cancer Res 2010 (Neoplasm Invasiveness...) : 4-MU induced caspase-8, caspase-9, and caspase-3 activation, PARP cleavage, upregulation of Fas-L, Fas, FADD and DR4, and downregulation of bcl-2, phosphorylated bad, bcl-XL, phosphorylated Akt, phosphorylated IKB, phosphorylated ErbB2, and phosphorylated epidermal growth factor receptor