Gene interactions and pathways from curated databases and text-mining

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IQGAP1 — RAC1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Fukata et al., J Biol Chem 1999 : Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin ... These results indicate that Cdc42 and Rac1 negatively regulate the IQGAP1 function by inhibiting the interaction of IQGAP1 with beta-catenin, leading to stabilization of the cadherin-catenin complex
Fukata et al., J Cell Sci 1999 : Activated Cdc42 and Rac1 inhibit IQGAP1 , thereby stabilizing the cadherin-catenins complex
Fukata et al., Mol Cell Biol 2001 : We have previously proposed that IQGAP1 , an effector of Rac1 and Cdc42, negatively regulates cadherin mediated cell-cell adhesion by interacting with beta-catenin and by causing the dissociation of alpha-catenin from cadherin-beta-catenin-alpha-catenin complexes and that activated Rac1 and Cdc42 positively regulate cadherin mediated cell-cell adhesion by inhibiting the interaction of IQGAP1 with beta-catenin
Noritake et al., Mol Biol Cell 2004 : Together, these results indicate that Rac1 enhances the accumulation of actin filaments, E-cadherin, and beta-catenin by acting on IQGAP1 and suggest that there exists a positive feedback loop comprised of "E-cadherin mediated cell-cell adhesion -- > Rac1 activation -- > actin-meshwork formation by IQGAP1 -- > increasing E-cadherin mediated cell-cell adhesion. ''
Takahashi et al., J Cell Physiol 2006 : While a small GTPase Rac and its effector IQGAP1 were associated with the E-cadherin-catenins complex, either OA or PP2A-A siRNA concomitantly induced the dissociation of IQGAP1, but not Rac , from the complex and the internalization of E-cadherin from the cell surface
Watanabe et al., Novartis Found Symp 2005 (Adenomatous Polyposis Coli) : Activated Rac1 and Cdc42 enhance the binding of IQGAP1 to CLIP-170, and capture GFP-CLIP-170 at the base of leading edges and filopodia, respectively
Brown et al., J Biol Chem 2007 (Salmonella Infections) : IQGAP1 regulates Salmonella invasion through interactions with actin, Rac1 , and Cdc42 ... Overexpression of IQGAP1 significantly increases the ability of Salmonella to enter host cells and required interaction with both actin and Cdc42/Rac1
Usatyuk et al., J Biol Chem 2009 (Hyperoxia) : Phospholipase D-mediated activation of IQGAP1 through Rac1 regulates hyperoxia induced p47phox translocation and reactive oxygen species generation in lung endothelial cells ... Hyperoxia caused rapid activation and redistribution of Rac1, and IQGAP1 to cell periphery, and down-regulation of Rac1 , and IQGAP1 attenuated hyperoxia induced tyrosine phosphorylation of Src and cortactin and ROS generation
Kozlova et al., Cell Signal 2012 : Depletion of IQGAP1 suppressed hyaluronan induced activation of Rac1 and enhanced the activation of RhoA
Kobayashi et al., J Biol Chem 1998 : We have previously identified IQGAP1 from bovine brain cytosol as a target for Rac1 by an affinity purification method