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NOS2 — RAC1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: NOS2 — RAC1 (direct interaction, pull down) Kuncewicz et al., American journal of physiology. Renal physiology 2001*
• IRef Hprd Interaction: NOS2 — RAC1 (two hybrid) Yokomori et al., Liver 2001*, Kuncewicz et al., American journal of physiology. Renal physiology 2001*
• IRef Hprd Interaction: NOS2 — RAC1 (in vitro) Yokomori et al., Liver 2001*, Kuncewicz et al., American journal of physiology. Renal physiology 2001*
• IRef Ophid Interaction: RAC1 — NOS2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: RAC1 — NOS2 (aggregation, confirmational text mining) Kuncewicz et al., American journal of physiology. Renal physiology 2001*

Text-mined interactions from Literome

Finder et al., Am J Physiol Lung Cell Mol Physiol 2001 (MAP Kinase Signaling System) : In this study, overexpression of constitutively active Rac1 or its dominant negative mutant did not affect IL-1beta induction of iNOS
Gonzalez et al., J Biol Chem 2006 : Taken together, these studies identify G protein betagamma subunits, Src kinase and the GEF Tiam1 as upstream modulators of S1P mediated Rac1 activation, and establish a central role for Rac1 in S1P mediated activation of PI 3-kinase/Akt/endothelial nitric-oxide synthase signaling in vascular endothelial cells
Sawada et al., Circ Res 2008 (Disease Models, Animal...) : Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1
Kim et al., J Pharmacol Sci 2010 (MAP Kinase Signaling System) : In addition, auranofin treatment activated cellular Rac1 and induced inducible nitric oxide synthase (iNOS) expression ... An inhibitor of Rac1 ( NSC23766 ) blocked the iNOS induction as well as Nrf2 activation and HO-1 expression