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BRCA1 — CDK2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: BRCA1 → CDK2 (directlyIncreases, BRCA1 Activity)
  Evidence: 10550055;10373534
• NCI Pathway Database BARD1 signaling events: CDK2/Cyclin E1 complex (CDK2-CCNE1) → BRCA1/BARD1 complex (BRCA1-BARD1) (modification, activates)
  Hayami et al., Cancer Res 2005*
  Evidence: assay, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: BRCA1 — CDK2 Ruffner et al., Mol Cell Biol 1999*, Wang et al., Oncogene 1997
• IRef Bind_translation Interaction: BRCA1 — CDK2 (affinity chromatography technology) Wang et al., Oncogene 1997
• IRef Biogrid Interaction: BRCA1 — CDK2 (physical association, affinity chromatography technology) Ruffner et al., Mol Cell Biol 1999*
• IRef Biogrid Interaction: BRCA1 — CDK2 (direct interaction, pull down) Ruffner et al., Mol Cell Biol 1999*
• IRef Biogrid Interaction: BRCA1 — CDK2 (direct interaction, pull down) Wang et al., Oncogene 1997
• IRef Biogrid Interaction: BRCA1 — CDK2 (direct interaction, enzymatic study) Chen et al., Cancer Res 1996*
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Ruffner et al., Mol Cell Biol 1999*, Wang et al., Oncogene 1997
• IRef Hprd Interaction: BRCA1 — CDK2 (in vitro) Ruffner et al., Mol Cell Biol 1999*
• IRef Hprd Interaction: BRCA1 — CDK2 (in vivo) Ruffner et al., Mol Cell Biol 1999*
• IRef Ophid Interaction: BRCA1 — CDK2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Ouchi et al., Proc Natl Acad Sci U S A 2000 : After IFN-gamma treatment, induction of the cyclin dependent kinase inhibitor, p21WAF1, was synergistically activated by BRCA1 , whereas the IRF-1 gene was unaffected
Hayami et al., Cancer Res 2005 (Breast Neoplasms...) : Here we show that the ubiquitin ligase activity of BRCA1-BARD1 is down-regulated by CDK2