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CD28 — IL13

Text-mined interactions from Literome

Oki et al., Eur J Immunol 2000 : The Stat6 association with CD28 is specifically induced by CD80 or CD86 ligand binding and is not dependent upon the secretion of IL-4 or IL-13
Okkenhaug et al., Nat Immunol 2001 : Nonetheless, this mutated form of CD28 still prevents the induction of anergy and promotes T cell proliferation, interleukin 2 secretion and B cell help
Kanda et al., Biochem Pharmacol 2001 : The AC inhibitor MDL 12,330A [cis-N- ( 2-phenylcyclopentyl ) azacyclotridec-1-en-2-amine hydrochloride ] completely blocked PHA- or anti-CD3/CD28 induced IL-13 production
Woerly et al., J Leukoc Biol 2002 (Hypereosinophilic Syndrome) : Human eosinophils express and release IL-13 following CD28 dependent activation
Fuss et al., J Clin Invest 2004 (Colitis, Ulcerative...) : We then show that stimulation of UC LPT cells bearing an NK marker ( CD161 ) with anti-CD2/anti-CD28 or with B cells expressing transfected CD1d induces substantial IL-13 production
Loza et al., Blood 2006 (MAP Kinase Signaling System) : The inhibition of CD3 + CD28 stimulated IL-13 production by both beta-agonist and PGE2 was reversed at low agonist concentrations, resulting in enhanced IL-13, but not IFN-gamma or IL-2, production
Ghosh et al., Cell Immunol 2006 : We find that T-cell activation by a combination of anti-CD3/anti-CD28/PHA induced a dominant IL-2, IL-13 , and Type-II interferon ( IFN-gamma ) response without major IL-12 and little Type-I interferon ( IFN-alphabeta ) release
Abreu et al., Arthritis Res Ther 2010 (Arthritis, Experimental...) : Ex vivo, Rac1 inhibitory peptide suppressed T-cell receptor/CD28 dependent production of tumor necrosis factor alpha, interferon gamma and interleukin-17 by T cells from collagen primed mice, and reduced induction of ICOS and CD154, T-cell costimulatory proteins important for B-cell help
Loza et al., Respir Res 2010 (Asthma) : An ex vivo system was used to characterize the regulation of IFN-gamma producing ( type 1 ) and IL-13 producing ( type 2 ) T cell accumulation in response to CD3+CD28 and IL-2 stimulation by flow cytometry
Smeets et al., BMC immunology 2012 : Translation towards a primary, whole blood setting and purified human CD4+ T cells revealed that PMA/CD3 stimulation induced a more pronounced Th1 specific, Lck and PKC? dependent IFN? production, whereas PMA/CD28 induced Th2 specific IL-5 and IL-13 production, independent of Lck activation
Ekman et al., Acta Derm Venereol 2013 (Psoriasis) : Anti-CD3 and anti-CD28 mediated activation of peripheral blood mononuclear cells ( PBMCs ) caused a higher secretion of Th2 cytokine interleukin (IL)-13 by PBMCs from patients with psoriasis than from healthy controls
Jeannin et al., J Biol Chem 1997 : The CD28 ligands, CD80 ( B7-1 ) and CD86 ( B7-2 ), are expressed on human tonsillar B cells, and their expression is up-regulated by IL-4, IL-13 , and/or an anti-CD40 monoclonal antibody ( mAb )
Marietta et al., J Immunol 1997 : Additionally, cross linking of CD28 simultaneously with PMA treatment of SCF derived mast cells resulted in an increased level of IL-13 transcripts
Dumont et al., J Immunol 1998 : PD98059 inhibited TNF-alpha, IL-3, granulocyte-macrophage (GM)-CSF, IFN-gamma, and to a lesser extent IL-6 and IL-10 production but enhanced IL-4, IL-5, and IL-13 production induced by CD3/PMA or CD3/CD28