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A2M — PRL

Text-mined interactions from Literome

Barkai et al., Mol Endocrinol 2000 : In summary, results of this study reveal that constitutive expression of SOCS-1 can prevent PRL signaling and that the lack of PRL induced expression of alpha2-macroglobulin in a defined decidual cell population is largely due to SOCS-1 expression in these cells
Gaddy-Kurten et al., Mol Endocrinol 1991 : Regulation of alpha 2-macroglobulin by luteinizing hormone and prolactin during cell differentiation in the rat ovary ... The obligatory requirement for PRL is specific ; associated with increased numbers of PRL binding sites ; mediated by time dependent appearance of alpha 2M in the endoplasmic reticulum ( 12 h ), Golgi apparatus ( 24 h ), and secretion vesicles ( 48 h ) ; and involves in part increased transcription of the alpha 2M gene
Dajee et al., Mol Endocrinol 1996 : Prolactin induction of the alpha 2-Macroglobulin gene in rat ovarian granulosa cells : stat 5 activation and binding to the interleukin-6 response element ... alpha 2-Macroglobulin (alpha 2M) is expressed at high levels in the corpus luteum of pregnant rats in response to PRL and rat placental lactogens ... Thus, the initial induction of the alpha 2M gene by PRL in differentiated rat granulosa cells involves, at least in part, the activation ( tyrosine phosphorylation ? ) of Stat 5
Dajee et al., Mol Endocrinol 1998 : In addition, the ORRE and PRLRE act independently of, rather than synergistically with, each other to regulate basal and PRL induced expression of alpha2M in ovarian luteal cells